Diet and alcohol consumption and lung cancer risk in the New York State cohort (United States)
Diet and alcohol consumption and lung cancer risk in the New York State cohort (United States)
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DOI：
10.1023/a:1018456127018
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发表时间：
1997-11-01
影响因子：
2.3
通讯作者：
Graham, S
中科院分区：
文献类型：
--
作者：
Bandera, EV;Freudenheim, JL;Graham, S
在纽约州队列（美国）的参与者中评估了饮食和酒精与肺癌之间的关系，该队列包括27，544名男性（395例）和20，456名女性（130例），他们在1980年完成了一份简短的邮寄问卷。在纽约州卫生部生命统计科和癌症登记处的协助下，对参与者进行了1987年的随访。在调整年龄、教育程度、吸烟/天、吸烟年数和总能量摄入后，观察到男性与维生素C、叶酸和类胡萝卜素呈负相关，与总脂肪、单不饱和脂肪和饱和脂肪呈正相关。在重度吸烟者中观察到的叶酸和饱和脂肪的关系更强。此外，叶酸，总脂肪和单不饱和脂肪的影响似乎仅限于鳞状细胞癌，我们没有发现胆固醇或多不饱和脂肪与肺癌有关的迹象，饮食似乎对女性肺癌风险没有发挥主要作用，尽管饮食调整永远不应被视为戒烟的替代品，它作为预防肺癌的一种额外策略的作用值得关注。
The relationship between diet and alcohol and lung cancer was evaluated among participants of the New York State Cohort (United States), comprising 27,544 men (395 cases) and 20,456 women (130 cases) who completed a brief mailed questionnaire in 1980. Participants were followed up through 1987 with the assistance of the New York State Department of Health's Vital Statistics Section and Cancer Registry, Among men, inverse relationships with vitamin C, folate, and carotenoids, and positive associations with total fat, monounsaturated and saturated fat were observed after adjusting for age, education, cigarettes/day, years smoking, and total energy intake. The relationships observed with folate and saturated fat were stronger for heavy smokers. Also, the effect of folate, total fat, and monounsaturated fat seemed to be limited to squamous cell carcinomas, We found no indication that cholesterol or polyunsaturated fat was associated with lung cancer, Diet did not appear to exert a major role on lung cancer risk among women, Although diet modification should never be considered a substitute for smoking cessation, its role as an additional strategy in lung cancer prevention deserves attention.