Systems Biology of Clostridium
Systems Biology of Clostridium
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梭菌系统生物学
DOI：
10.1142/9781783264414_0007
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
JABBARI S
中科院分区：
文献类型：
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作者：
JABBARI S
已知许多细菌调节基因与细胞密度一致，这种现象称为“群体感应”。随机性和确定性建模方法揭示了群体感应系统以前未知的属性，并产生了新的，实验可检验的假设。这一章的重点是agr型群体感应系统，它依赖于一个自动诱导的环肽信号的生产，通过一个经典的双组分系统。agr依赖的群体感应是目前最好的理解在葡萄球菌物种，但同源系统存在于广泛的革兰氏阳性细菌，特别是成员的classClostridia。提出了葡萄球菌聚集系统的确定性建模方法。以丙酮丁醇梭菌为例，研究了现有模型如何适用于其他物种中存在的农业系统。
Many bacteria are known to regulate genes in concert with cell density, a phenomenon termed ‘quorum sensing’. Stochastic and deterministic modelling approaches have revealed previously unknown properties of quorum sensing systems and generated novel, experimentally testable hypotheses. This chapter focuses onagr-type quorum sensing systems, which rely on the production of an autoinducing cyclic peptide signal that is sensed via a classical two-component system.agr-dependent quorum sensing is currently best understood in staphylococcal species, but homologous systems are present in a wide range of Gram-positive bacteria, particularly members of the classClostridia. Deterministic modelling approaches for the staphylococcalagrsystems are presented. UsingClostridium acetobutylicumas an example, it is investigated how existing models can be adapted to investigateagrsystems present in other species.