Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod
Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod
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DOI：
10.1111/j.1365-2869.2007.00581.x
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发表时间：
2007-06-01
影响因子：
4.4
通讯作者：
Dijk, Derk-Jan
中科院分区：
文献类型：
--
作者：
Vandewalle, Gilles;Middleton, Benita;Dijk, Derk-Jan
心率（HR）和心率变异性（HRV）在24小时内发生显著波动。尽管存在争议，但这种24小时节律被认为是由睡眠-觉醒/休息-活动周期以及内源性昼夜节律驱动的。我们量化的内源性昼夜节律的HR和HRV和研究是否可以改变这种节奏，通过重复褪黑激素给药，同时暴露于一个改变的光周期。8名健康男性（年龄24.4 ± 4.4岁）参加了一项双盲交叉设计研究。在这两种情况下，志愿者被安排到16小时-8小时休息：清醒和黑暗：光周期连续9天之前和之后的29小时恒定例程（CR）的内源性昼夜节律的评估。在延长睡眠时间开始时给予褪黑激素（1.5 mg）或安慰剂。对于CR的所有多导睡眠图验证的清醒期，我们计算了R-R间期功率谱的高（HF）和低（LF）频带、正常-正常（NN）间期的标准差（SDNN）和连续NN间期均方差的平方根（rMSSD）。HR和HRV变量显示了稳健的内源性昼夜节律，分别在下午（16：36小时）和清晨（05：00至06：59小时）具有拟合最大值。褪黑激素治疗使HR、HF、SDNN和rMSSD阶段提前，这些变化显著大于安慰剂治疗后。我们的结论是内源性昼夜节律影响自主控制的HR和这些内源性节律的时间可以改变延长睡眠/休息发作和相关的光周期的变化，以及褪黑激素治疗。
Heart rate (HR) and heart rate variability (HRV) undergo marked fluctuations over the 24-h day. Although controversial, this 24-h rhythm is thought to be driven by the sleep-wake/rest-activity cycle as well as by endogenous circadian rhythmicity. We quantified the endogenous circadian rhythm of HR and HRV and investigated whether this rhythm can be shifted by repeated melatonin administration while exposed to an altered photoperiod. Eight healthy males (age 24.4 +/- 4.4 years) participated in a double-blind cross-over design study. In both conditions, volunteers were scheduled to 16 h-8 h rest : wake and dark : light cycles for nine consecutive days preceded and followed by 29-h constant routines (CR) for assessment of endogenous circadian rhythmicity. Melatonin (1.5 mg) or placebo was administered at the beginning of the extended sleep opportunities. For all polysomnographically verified wakefulness periods of the CR, we calculated the high- (HF) and low- (LF) frequency bands of the power spectrum of the R-R interval, the standard deviation of the normal-to-normal (NN) intervals (SDNN) and the square root of the mean-squared difference of successive NN intervals (rMSSD). HR and HRV variables revealed robust endogenous circadian rhythms with fitted maxima, respectively, in the afternoon (16:36 hours) and in the early morning (between 05:00 and 06:59 hours). Melatonin treatment phase-advanced HR, HF, SDNN and rMSSD, and these shifts were significantly greater than after placebo treatment. We conclude that endogenous circadian rhythmicity influences autonomic control of HR and that the timing of these endogenous rhythms can be altered by extended sleep/rest episodes and associated changes in photoperiod as well as by melatonin treatment.