Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions.
Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions.
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DOI：
10.1177/2398212820972599
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发表时间：
2020-01
影响因子：
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通讯作者：
McGregor A
中科院分区：
文献类型：
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作者：
Poulter SL;Kosaki Y;Sanderson DJ;McGregor A
我们研究的作用，海马和背外侧纹状体的代表性的环境几何形状使用一个自发的物体识别程序。老鼠被放置在风筝形状的竞技场中，并被允许在每个直角角落探索两个不同的物体。在另一个房间里，大鼠被放入一个长方形的竞技场，其中有两个相同的复制品，复制品来自探索阶段的两个物体中的一个，每个复制品位于两个相邻的直角角落中，两个直角角落被一堵长墙隔开。探索这两个物体所花费的时间被记录作为识别记忆的衡量标准。由于两个物体相对于房间（探索和测试阶段不同）和全局几何形状（探索和测试阶段也不同）处于不同的位置，因此物体的差异探索必须是相对于其局部几何背景对物体的初始习惯化的结果。结果表明，海马和背外侧纹状体损伤大鼠与假手术对照组相比，在处理环境的局部几何特征的损害，虽然对照实验表明，这些大鼠在一个标准的物体识别任务中没有受损。背外侧纹状体以前曾被牵连在自我中心的路线学习，但结果表明，一个意想不到的作用，背外侧纹状体在处理的空间布局的环境。结果提供了第一个证据表明，海马和背外侧纹状体的病变损害了自发编码的局部环境几何特征。
We examined the role of the hippocampus and the dorsolateral striatum in the representation of environmental geometry using a spontaneous object recognition procedure. Rats were placed in a kite-shaped arena and allowed to explore two distinctive objects in each of the right-angled corners. In a different room, rats were then placed into a rectangular arena with two identical copies of one of the two objects from the exploration phase, one in each of the two adjacent right-angled corners that were separated by a long wall. Time spent exploring these two objects was recorded as a measure of recognition memory. Since both objects were in different locations with respect to the room (different between exploration and test phases) and the global geometry (also different between exploration and test phases), differential exploration of the objects must be a result of initial habituation to the object relative to its local geometric context. The results indicated an impairment in processing the local geometric features of the environment for both hippocampus and dorsolateral striatum lesioned rats compared with sham-operated controls, though a control experiment showed these rats were unimpaired in a standard object recognition task. The dorsolateral striatum has previously been implicated in egocentric route-learning, but the results indicate an unexpected role for the dorsolateral striatum in processing the spatial layout of the environment. The results provide the first evidence that lesions to the hippocampus and dorsolateral striatum impair spontaneous encoding of local environmental geometric features.