Association between late-life social activity and motor decline in older adults.
Association between late-life social activity and motor decline in older adults.
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DOI：
10.1001/archinternmed.2009.135
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发表时间：
2009-06-22
影响因子：
--
通讯作者：
Bennett, David A.
中科院分区：
文献类型：
--
作者：
Buchman, Aron S.;Boyle, Patricia A.;Wilson, Robert S.;Fleischman, Debra A.;Leurgans, Sue;Bennett, David A.
运动功能丧失是衰老的常见后果，但对预测特发性运动衰退的因素知之甚少。我们研究了906名没有痴呆、中风史或帕金森病的人，他们参加了Rush记忆和衰老项目。在基线上，他们评估了自己参加普通社会活动的频率。结果是基于9项肌肉力量和9项运动表现的全球运动功能的年度变化。基线时的平均社交活动得分为2.6 (SD=0.58)，得分越高表明参与社交活动的频率越高。在广义估计方程模型中，控制年龄、性别和教育程度，运动功能下降约0.05个单位/年[估计，0.016；95%ci (-0.057, -0.041)；p = 0.017)。社交活动每减少1分，运动功能下降的速度就会加快33%[估计值，0.016；95%ci (0.003, 0.029)；p = 0.017)。每年运动能力下降的数量与死亡风险增加40%以上（风险比：1.44;95%CI: 1.30, 1.60）和事件Katz残疾风险增加65%（风险比：1.65;95%CI: 1.48, 1.83）相关。社交活动与运动功能变化的关联在人口统计学上没有变化，并且在控制了潜在的混杂因素（包括晚年身体和认知活动、残疾、整体认知、抑郁症状、身体成分和慢性疾病）后没有变化[估计值，0.025；95%ci (0.005, 0.045)；p = 0.010)。较少参加社会活动与老年运动能力下降的速度更快有关。
Loss of motor function is a common consequence of aging, but little is known about factors that predict idiopathic motor decline. We studied 906 persons without dementia, history of stroke or Parkinson's disease participating in the Rush Memory and Aging Project. At baseline, they rated their frequency of participation in common social activities. Outcome was annual change in global motor function, based on nine measures of muscle strength and nine motor performances. Mean social activity score at baseline was 2.6 (SD=0.58), with higher scores indicating more frequent participation in social activities. In a generalized estimating equation model, controlling for age, sex and education, motor function declined by about 0.05 unit/year [Estimate, 0.016; 95%CI (-0.057, -0.041); p=0.017]. Each 1-point decrease in social activity was associated with about a 33% more rapid rate of decline in motor function [Estimate, 0.016; 95%CI (0.003, 0.029); p=0.017)]. This amount of annual motor decline was associated with a more than 40% increased risk of death (Hazard Ratio: 1.44; 95%CI: 1.30, 1.60) and 65% increased risk of incident Katz disability (Hazard Ratio: 1.65; 95%CI: 1.48, 1.83). The association of social activity with change in motor function did not vary along demographic lines and was unchanged after controlling for potential confounders including late-life physical and cognitive activity, disability, global cognition, depressive symptoms, body composition and chronic medical conditions [Estimate, 0.025; 95%CI (0.005, 0.045); p=0.010]. Less frequent participation in social activities is associated with a more rapid rate of motor decline in old age.
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