Structure tuning of lithium amide for asymmetric 1,4-addition to cinnamate and subsequent demasking
Structure tuning of lithium amide for asymmetric 1,4-addition to cinnamate and subsequent demasking
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DOI：
10.1016/j.tetlet.2004.10.050
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发表时间：
2004-12-06
影响因子：
1.8
通讯作者：
Tomioka, K
中科院分区：
文献类型：
--
作者：
Sakai, T;Doi, H;Tomioka, K
由苄基-N-TMS-、烯丙基-N-叔丁基二甲基甲基胺和二异丙胺衍生的锂酰胺化合物的系统结构调整导致了几个候选化合物，包括在1，4-不对称加成(91%ee)和与10%Pd/C-H-2在甲醇中氢解生成β-氨基酸酯方面表现出很高的性能的菲-9-甲胺。(C)2004爱思唯尔有限公司。保留所有权利。
Systematic structure tuning of lithium amides derived from benzyl-N-TMS-, allyl-N-TBDMS-, and diisopropylamines lead to several candidates including anthracen-9-ylmethanamine which provided high performance in the enantioselective 1,4-addition (91% ee) and following hydrogenolysis with 10% Pd/C-H-2 in methanol to afford beta-amino ester. (C) 2004 Elsevier Ltd. All rights reserved.