Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost:: A planning study
Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost:: A planning study
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DOI：
10.1016/j.ijrobp.2007.05.038
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发表时间：
2007-10-01
影响因子：
7
通讯作者：
Mehta, Minesh P.
中科院分区：
文献类型：
--
作者：
Gutierrez, Alonso N.;Westerly, David C.;Mehta, Minesh P.
目的：评估使用断层放射治疗进行海马回避的全脑放疗的可行性，假设可以降低记忆功能下降的风险，并同时整合增强脑转移以改善颅内肿瘤控制。方法和材料：10 名接受放射外科和全脑放疗治疗的患者接受了使用原始计算机断层扫描和磁共振成像-计算机断层扫描融合定义的目标和正常结构轮廓的断层放射治疗的重复计划。单独轮廓的海马体用作剂量限制结构（最大直径 = 2.0 cm，病变部位 70.8 Gy）
Purpose: To evaluate the feasibility of using tomotherapy to deliver whole brain radiotherapy with hippocampal avoidance, hypothesized to reduce the risk of memory function decline, and simultaneously integrated boost to brain metastases to improve intracranial tumor control.Methods and Materials: Ten patients treated with radiosurgery and whole brain radiotherapy underwent repeat planning using tomotherapy with the original computed tomography scans and magnetic resonance imaging-computed tomography fusion-defined target and normal structure contours. The individually contoured hippocampus was used as a dose-limiting structure (= 2.0 cm in the maximal diameter and 70.8 Gy to lesions