The Effect of Periodontal Treatment on Serum Leptin, Interleukin-6, and C-Reactive Protein
The Effect of Periodontal Treatment on Serum Leptin, Interleukin-6, and C-Reactive Protein
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DOI：
10.1902/jop.2010.090741
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发表时间：
2010-08-01
影响因子：
4.3
通讯作者：
Yoshie, Hiromasa
中科院分区：
文献类型：
--
作者：
Shimada, Yasuko;Komatsu, Yasutaka;Yoshie, Hiromasa
背景：既往研究认为牙周炎与肥胖及代谢综合征密切相关。瘦素是一种由脂肪组织产生的多功能激素，与牙周炎有关。本研究旨在探讨牙周治疗对慢性牙周炎（CP）患者血清瘦素及其他细胞因子水平的影响。结果：牙周炎患者血清瘦素、IL-6、CRP水平与健康对照组比较差异有统计学意义（P= 0.0018、P=0.0064、P=0.0095），血清脂联素、肿瘤坏死因子-α、白细胞介素-6（IL-6）、C反应蛋白（CRP）水平与健康对照组比较差异有统计学意义（P =0.0095）。血清瘦素水平与平均探诊深度、平均临床附着水平、平均牙槽骨丢失和体重指数相关。血清瘦素水平与IL-6和CRP水平显著相关。牙周非手术治疗后，血清瘦素、IL-6和CRP水平显著降低（治疗前后的平均SD，P值分别为：瘦素，8.02 ± 5.5，7.10 ± 4.4，P= 0.015; IL-6，1.73 ± 1.02，1.36 ± 0.73，P=0.048; CRP水平分别为802.0 ± 1065，491.2 ± 479.3，P=0.047）。结论：periodicals治疗可有效降低血清瘦素、IL-6和CRP水平。提示瘦素、IL-6和CRP可能是代谢综合征与牙周炎之间的中介因素。J Periodontol 2010; 81：1118-1123.
Background: Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported to be related to periodontitis. This study investigates the effects of periodontal treatment on the serum levels of leptin and other cytokines in patients with chronic periodontitis (CP).Methods: Serum samples were taken from 33 CP patients (22 non-smokers, 11 smokers) and 18 healthy subjects. The serum leptin, adiponectin, tumor necrosis factor-a, interleukin (IL)-6, and C-reactive protein (CRP) levels were measured before and after non-surgical periodontal treatment.Results: Significant differences between healthy and CP patients were found in serum leptin, IL-6, and CRP levels (P= 0.0018, P=0.0064, and P=0.0095, respectively). The serum leptin level was associated with mean probing depth, mean clinical attachment level, mean alveolar bone loss, and body mass index. There were significant associations between serum leptin levels and 1L-6 and CRP levels. After non-surgical periodontal treatment, serum leptin, IL-6, and CRP levels were significantly decreased (mean SD before and after, P value, respectively: leptin, 8.02 +/- 5.5, 7.10 +/- 4.4, P= 0.015; IL-6, 1.73 +/- 1.02, 1.36 +/- 0.73, P=0.048; and CRP, 802.0 +/- 1065, 491.2 +/- 479.3, P=0.047).Conclusions: Periodontal treatment is effective in reducing serum leptin, IL-6, and CRP levels. The results suggest that leptin, IL-6, and CRP could be mediating factors that connect metabolic syndrome and periodontitis. J Periodontol 2010; 81:1118-1123.