Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes
Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes
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DOI：
10.1167/iovs.16-21289
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发表时间：
2017-04-01
影响因子：
4.4
通讯作者：
Sarraf, David
中科院分区：
文献类型：
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作者：
Al-Sheikh, Mayss;Phasukkijwatana, Nopasak;Sarraf, David
目的.应用定量光学相干断层扫描血管造影（OCTA）技术研究近视眼视网膜毛细血管和脉络膜毛细血管（CC）的形态结构。使用配备AngioVue的RTVue-XR Avanti获得3 3 3 mm的黄斑OCTA图像。使用正面投影图像分析视网膜毛细血管微血管层和CC的定量测量。血管密度和分形维数的浅表和深层视网膜毛细血管丛，面积和密度的流量减少CC进行了分析，量化，并与年龄匹配的对照组进行比较。选择近视眼50只眼和年龄匹配的健康眼34只眼。近视眼视网膜毛细血管密度和血管分支复杂度均明显低于对照组（P < 0.001和P = 0.001）。CC中的流动空隙总数较低（108.93 vs. 138.63，P = 0.001），但总的和平均的流动空隙面积显著更高（总面积3.715 +/- 0.257 vs. 3.596 +/- 0.194 mm（2），P = 0.026;平均面积0.044 +/- 0.029 vs. 0.028 +/- 0.010 mm（2），P = 0.002）。与正常对照组相比，近视组的平均脉络膜厚度较低（123.538 +/- 73.477对246.97 +/- 41.745 lm，P < 0.05），与未形成漆样裂纹（LC）的近视眼相比，LC眼的平均脉络膜厚度显著降低（P = 0.003）。在近视眼中，脉络膜厚度与CC的定量参数之间没有相关性。在高度近视眼中，视网膜毛细血管微血管的密度降低，CC中的血流缺损面积增加。近视眼微血管改变的相关性值得进一步研究。
PURPOSE. To study the retinal capillary microvasculature and the choriocapillaris (CC) in myopic eyes using quantitative optical coherence tomography angiography (OCTA) analysis.METHODS. Macular OCTA images of 3 3 3 mm were obtained using the RTVue-XR Avanti with AngioVue. Quantitative measurements of the retinal capillary microvascular layers and the CC were analyzed using en face projection images. Vessel density and fractal dimension of the superficial and deep retinal capillary plexus, and area and density of flow reduction in the CC were analyzed, quantified, and compared with an age-matched control group.RESULTS. Fifty eyes with myopia and 34 age-matched healthy eyes were included in this study. The vessel density and the vessel branching complexity using fractal dimension of the retinal capillary microvasculature were significantly lower in myopic eyes (P < 0.001 and P = 0.001). The total number of flow voids in the CC was lower (108.93 vs. 138.63, P = 0.001) but the total and average flow void area was significantly higher (total area 3.715 +/- 0.257 vs. 3.596 +/- 0.194 mm(2), P = 0.026; average area 0.044 +/- 0.029 vs. 0.028 +/- 0.010 mm(2), P = 0.002) compared with the healthy control group. Average choroidal thickness was lower in the myopic group versus the normal control cohort (123.538 +/- 73.477 vs. 246.97 +/- 41.745 lm, P < 0.05) and significantly reduced in eyes with lacquer cracks (LC) compared with myopic eyes without LC formation (P = 0.003). There was no correlation between choroidal thickness and quantitative parameters of the CC in the myopic eyes.CONCLUSIONS. The density of the retinal capillary microvasculature is reduced and the area of flow deficit in the CC is increased in eyes with greater myopia. The relevance of microvascular alterations in the setting of myopia warrants further study.