Petrosiols A-E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata
Petrosiols A-E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata
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DOI：
10.1016/j.tet.2012.10.063
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发表时间：
2013-01-07
期刊：
影响因子：
2.1
通讯作者：
Ojika, Makoto
中科院分区：
文献类型：
--
作者：
Horikawa, Kouhei;Yagyu, Takuya;Ojika, Makoto
从冲绳海绵 Petrosia Strongylata 的提取物中，分离出五种新型炔属代谢物：岩油醇 A (1) E (5)，并进行了化学表征。这些化合物诱导 PC12 细胞的神经生长因子 (NGF) 样神经元分化。石油醇、其衍生物和一些相关已知化合物的结构活性关系表明稀有的 2,4-二炔-1,6,7,8-四醇片段对于石油醇的神经营养活性的重要性。 (C) 2012 Elsevier Ltd. 保留所有权利。
From an extract of the Okinawan sponge Petrosia strongylata, five novel acetylenic metabolites, petrosiols A (1) E (5), were isolated and chemically characterized. These compounds induced nerve growth factor (NGF)-like neuronal differentiation of PC12 cells. The structure activity relationships of the petrosiols, their derivatives, and some related known compounds suggest the importance of the rare 2,4-diyne-1,6,7,8-tetraol fragment for the neurotrophic activity of the petrosiols. (C) 2012 Elsevier Ltd. All rights reserved.