Comparative virulence of porcine Haemophilus bacteria.
Comparative virulence of porcine Haemophilus bacteria.
复制标题
猪嗜血杆菌的毒力比较。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
K. Gilbride
中科院分区：
文献类型：
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作者：
S. Rosendal;D. Boyd;K. Gilbride
用特定剂量的细菌，通过无特定病原体猪的下呼吸道，比较胸膜肺炎嗜血杆菌血清型1、2、3、7菌株和"小群"菌株和副猪嗜血杆菌菌株的毒力。胸膜肺炎嗜血杆菌，菌株W，血清型1，以1 × 10（8）菌落形成单位给药，在4头猪中产生致死性急性胸膜肺炎。在四组猪中，分别给予1 × 10（7）、1 × 10（6）、1 × 10（5）和1 × 10（4）的同一菌株，诱发非致死性局限性肺坏死。当接种1 × 10（7）菌落形成单位的H.胸膜肺炎，菌株Shope 4074，血清型1和1 × 10（7）菌落形成单位的H。胸膜肺炎，菌株WF83，血清型7。在给予1 × 10（8）菌落形成单位的血清型2型菌株1536的20头猪中，2头死于急性胸膜肺炎，18头出现肺坏死或坏死和胸膜炎病变。剂量为4 × 10（9）菌落形成单位的菌株BC 181（血清型3）诱导肺坏死，与给予10（7）菌落形成单位或更少的菌株W（血清型1）的猪中的病变相似，表明血清型3菌株的毒力较低。在接种4 × 10（9）个菌落形成单位的"少数群体"菌株7ATS的4头猪中，未诱导临床体征，但诱导了肺纤维化和胸膜粘连的局灶性区域。同样，接种"少数群体"菌株33PN的4头猪未显示临床体征，但出现局灶性坏死和纤维化肺部病变以及胸膜粘连。（250字处删节）
The virulence of strains of Haemophilus pleuropneumoniae serotype 1, 2, 3, 7 and strains of the "minor-group" and Haemophilus parasuis were compared by inoculating specific pathogen-free pigs into the lower airways with specified doses of bacteria. Haemophilus pleuropneumoniae, strain W, serotype 1, given in 1 X 10(8) colony-forming units, produced a lethal acute pleuropneumonia in four pigs. Nonlethal localized pulmonary necrosis was induced in four groups of two pigs given 1 X 10(7), 1 X 10(6), 1 X 10(5) and 1 X 10(4) respectively of the same strain. Two groups of four pigs developed chronic lesions when inoculated with 1 X 10(7) colony-forming units of H. pleuropneumoniae, strain Shope 4074, serotype 1 and 1 X 10(7) colony-forming units of H. pleuropneumoniae, strain WF83, serotype 7, respectively. Of 20 pigs given 1 X 10(8) colony-forming units of strain 1536, serotype 2, two died of acute pleuropneumonia and 18 had lesions of pulmonary necrosis or abscessation and pleuritis. A dose of 4 X 10(9) colony-forming units of strain BC181, serotype 3, induced pulmonary necrosis similar to the lesions in pigs given 10(7) colony-forming units or less of strain W, serotype 1, suggesting that the serotype 3 strain is less virulent. No clinical signs, but focal areas of pulmonary fibrosis and pleural adhesions were induced in four pigs inoculated with 4 X 10(9) colony-forming units of the "minor-group" strain 7ATS. Similarly, four pigs inoculated with "minor-group" strain 33PN did not show clinical signs, but had focal necrotic and fibrotic pulmonary lesions and pleural adhesions.(ABSTRACT TRUNCATED AT 250 WORDS)