Dexmedetomidine Attenuates Neuropathic Pain by Inhibiting P2X7R Expression and ERK Phosphorylation in Rats.
Dexmedetomidine Attenuates Neuropathic Pain by Inhibiting P2X7R Expression and ERK Phosphorylation in Rats.
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右美托咪定通过抑制大鼠 P2X7R 表达和 ERK 磷酸化来减轻神经病理性疼痛。
DOI：
10.5607/en.2018.27.4.267
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发表时间：
2018-08
影响因子：
2.4
通讯作者：
Yao YX
中科院分区：
文献类型：
--
作者：
Lin JP;Chen CQ;Huang LE;Li NN;Yang Y;Zhu SM;Yao YX
α2-Adrenoceptor agonists attenuate hypersensitivity under neuropathic conditions. However, the mechanisms underlying this attenuation remain largely unknown. In the present study, we explored the potential roles of purinergic receptor 7 (P2X7R)/extracellular signal-regulated kinase (ERK) signaling in the anti-nociceptive effect of dexmedetomidine in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve. An animal model of CCI was adopted to mimic the clinical neuropathic pain state. Behavioral hypersensitivity to mechanical and thermal stimuli was determined by von Frey filament and Hargreaves' tests, and the spinal P2X7R expression level and ERK phosphorylation were analyzed using western blot analysis and immunohistochemistry. In parallel with the development of mechanical and thermal hyperalgesia, a significant increase in P2X7R expression was noted in the ipsilateral spinal cord on day 7 after CCI. Intrathecal administration of dexmedetomidine (2.5 µg) for 3 days not only attenuated neuropathic pain but also inhibited the CCI-induced P2X7R upregulation and ERK phosphorylation. Intrathecal dexmedetomidine administration did not produce obvious effects on locomotor function. The present study demonstrated that dexmedetomidine attenuates the neuropathic pain induced by CCI of the sciatic nerve in rats by inhibiting spinal P2X7R expression and ERK phosphorylation, indicating the potential therapeutic implications of dexmedetomidine administration for the treatment of neuropathic pain.
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影响因子：
4.4
作者：
Falsig, J;Pörzgen, P;Leist, M
通讯作者：
Leist, M
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影响因子：
4
作者：
Chen, Meng-Ling;Cao, Hong;Zhao, Zhi-Qi
通讯作者：
Zhao, Zhi-Qi
小胶质细胞 P2X7 受体和下游信号通路参与脊髓伤害性反应的长期增强
影响因子：
15.1
作者：
Chu, Yu-Xia;Zhang, Yan;Zhao, Zhi-Qi
通讯作者：
Zhao, Zhi-Qi
影响因子：
4.7
作者：
Gao YJ;Ji RR
通讯作者：
Ji RR
影响因子：
5.3
作者：
Ji, RR;Befort, K;Woolf, CJ
通讯作者：
Woolf, CJ