ETHNIC-DIFFERENCES IN HUMAN-LEUKOCYTE ANTIGEN MARKERS OF SUSCEPTIBILITY TO IDDM
ETHNIC-DIFFERENCES IN HUMAN-LEUKOCYTE ANTIGEN MARKERS OF SUSCEPTIBILITY TO IDDM
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DOI：
10.2337/diacare.17.2.132
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发表时间：
1994-02-01
期刊：
影响因子：
16.2
通讯作者：
HAMMAN, RF
中科院分区：
文献类型：
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作者：
CRUICKSHANKS, KJ;JOBIM, LF;HAMMAN, RF
目的-为了确定是否遗传差异解释较低的风险发展胰岛素依赖型糖尿病（IDDM）的西班牙裔与非西班牙裔白色儿童在Colorado.RESEARCH DESIGN AND METHODS -西班牙裔（n = 62）和非西班牙裔白色（n = 82）与IDDM从科罗拉多IDDM登记处和健康，非糖尿病对照受试者进行了招募。人类白细胞抗原（HLA）血清学分型和DQA 1和DQB 1等位基因的序列特异性寡核苷酸分型进行了performed. Results-HLA和等位基因与胰岛素依赖型糖尿病在两个种族群体中是相似的。HLA-DR 3和HLA-DR 4在两个民族的IDDM患者中更为常见。无论种族背景如何，在57位编码天冬氨酸（Asp）的DQB 1等位基因的受试者患IDDM的可能性较小。HLA-DR 3在西班牙裔受试者中比非西班牙裔白色对照受试者更不常见（4.4%对17.5%，西班牙裔对非西班牙裔白人，P = 0.04）。结论-这些数据表明，西班牙裔人群中HLA-DR 3的患病率较低，这一模式与美洲印第安人混合物的存在相一致，可以解释西班牙裔人群中IDDM的发病率较低。
OBJECTIVE - To determine whether genetic differences explain the lower risk of developing insulin-dependent diabetes mellitus (IDDM) for Hispanic versus non-Hispanic white children in Colorado.RESEARCH DESiGN AND METHODS - Hispanic (n = 62) and non-Hispanic white (n = 82) subjects with IDDM identified from the Colorado IDDM Registry and healthy, nondiabetic control subjects were recruited. Human leukocyte antigen (HLA) serologic typing and sequence-specific oligonucleotide typing of DQA1 and DQB1 alleles were performed.RESULTS - HLA and allele associations with IDDM were similar in both ethnic groups. HLA-DR3 and HLA-DR4 were more common in IDDM subjects in both ethnic groups. Subjects with DQB1 alleles encoding aspartic acid (Asp) in position 57 were less likely to have IDDM, irrespective of ethnic background. HLA-DR3 was less common among Hispanic subjects than non-Hispanic white control subjects (4.4 vs. 17.5%, Hispanics vs. non-Hispanic whites, P = 0.04).CONCLUSIONS - These data suggest that the lower prevalence of HLA-DR3 in the Hispanic population, a pattern consistent with the presence of Amerindian admixture, may explain the lower rate of IDDM in the Hispanic population.