Japanese encephalitis: the virus and vaccines.
Japanese encephalitis: the virus and vaccines.
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DOI：
10.4161/hv.26902
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发表时间：
2014
影响因子：
4.8
通讯作者：
Lee YM
中科院分区：
文献类型：
--
作者：
Yun SI;Lee YM
日本脑炎（乙脑）是一种由人畜共患的蚊媒黄病毒——日本脑炎病毒（JEV）引起的中枢神经系统传染病。乙脑病毒在亚洲和西太平洋大部分地区流行，有超过40亿人面临感染风险。在缺乏抗病毒干预的情况下，疫苗接种是针对乙脑病毒感染建立长期可持续保护的唯一策略。在过去的半个世纪里，一种小鼠脑源性灭活疫苗在国际上被用于主动免疫。然而，迄今为止，乙脑病毒仍然是一种具有全球意义的临床重要、新出现和再出现的人类病原体。近年来，已停止生产小鼠脑源性疫苗，但在世界各地可获得3种新的细胞培养源性疫苗。本文综述了乙脑病毒生物学的研究现状，总结了乙脑病毒疫苗的4种类型，并讨论了感染性乙脑病毒cDNA技术在未来疫苗开发中的潜力。
Japanese encephalitis (JE) is an infectious disease of the central nervous system caused by Japanese encephalitis virus (JEV), a zoonotic mosquito-borne flavivirus. JEV is prevalent in much of Asia and the Western Pacific, with over 4 billion people living at risk of infection. In the absence of antiviral intervention, vaccination is the only strategy to develop long-term sustainable protection against JEV infection. Over the past half-century, a mouse brain-derived inactivated vaccine has been used internationally for active immunization. To date, however, JEV is still a clinically important, emerging, and re-emerging human pathogen of global significance. In recent years, production of the mouse brain-derived vaccine has been discontinued, but 3 new cell culture-derived vaccines are available in various parts of the world. Here we review current aspects of JEV biology, summarize the 4 types of JEV vaccine, and discuss the potential of an infectious JEV cDNA technology for future vaccine development.