Biomimetic peptoid oligomers as dual-action antifreeze agents
Biomimetic peptoid oligomers as dual-action antifreeze agents
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DOI：
10.1073/pnas.1212826109
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发表时间：
2012-12-04
影响因子：
11.1
通讯作者：
Ward, Michael D.
中科院分区：
文献类型：
--
作者：
Huang, Mia L.;Ehre, David;Ward, Michael D.
天然肽和蛋白质影响无机晶体材料形成的能力促使设计合成化合物来调节晶体生长，包括水的冻结和冰晶的生长。尽管它们的多功能性和易于结构修饰，但肽模拟物寡聚物尚未被广泛探索作为结晶调节剂。这份报告描述了一个库的合成N-取代甘氨酸类肽低聚物，具有“双重作用”的抗冻活性，作为例证的冰晶生长抑制伴随着熔化温度降低。我们研究了负责这些现象的结构特征，并观察到，类肽抗冻活性取决于低聚物的骨架结构和侧链的化学组成。这些研究揭示了类肽作为冰结晶调节剂的能力，从而能够发现一个独特而多样的合成低聚物家族，这些低聚物具有在食品生产和生物医学中作为防冻剂的潜力。
The ability of natural peptides and proteins to influence the formation of inorganic crystalline materials has prompted the design of synthetic compounds for the regulation of crystal growth, including the freezing of water and growth of ice crystals. Despite their versatility and ease of structural modification, peptidomimetic oligomers have not yet been explored extensively as crystallization modulators. This report describes a library of synthetic N-substituted glycine peptoid oligomers that possess "dual-action" antifreeze activity as exemplified by ice crystal growth inhibition concomitant with melting temperature reduction. We investigated the structural features responsible for these phenomena and observed that peptoid antifreeze activities depend both on oligomer backbone structure and side chain chemical composition. These studies reveal the capability of peptoids to act as ice crystallization regulators, enabling the discovery of a unique and diverse family of synthetic oligomers with potential as antifreeze agents in food production and biomedicine.