Protection from infection with severe acute respiratory syndrome coronavirus in a chinese hamster model by equine neutralizing F(ab')2
Protection from infection with severe acute respiratory syndrome coronavirus in a chinese hamster model by equine neutralizing F(ab')2
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通过马中和 F(ab')2 保护中国仓鼠模型免受严重急性呼吸综合征冠状病毒感染。
DOI：
10.1089/vim.2007.0038
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发表时间：
2007-09-01
期刊：
影响因子：
2.2
通讯作者：
Wang, Xiliang
中科院分区：
文献类型：
--
作者：
Luo, Deyan;Ni, Bing;Wang, Xiliang
为了保证潜在的临床测试，马抗严重急性呼吸综合征冠状病毒(SARS-CoV)F(ab‘)(2)需要在尽可能多的动物模型中进行评估。在本研究中，我们建立了一种新的动物模型--中国仓鼠，它对SARS-CoV感染易感。SARS冠状病毒能在动物肺内有效繁殖并维持高水平1wk。在预防环境中，所有动物都被保护免受SARS-CoV感染。此外，当用于治疗时，这种抗体导致受感染动物肺部的病毒载量减少了约4log(10)。肺组织的病理改变与抗体接种剂量密切相关。马抗SARS冠状病毒F(ab‘)(2)在几种动物模型中具有良好的预防和治疗作用，包括本研究中描述的新的中国仓鼠模型，为其潜在的临床研究提供了令人兴奋的数据。
To warrant potential clinical testing, the equine anti-severe acute respiratory syndrome coronavirus (SARS-CoV) F(ab')(2) requires evaluation in as many animal models as possible. In this study, we established a new animal model, the Chinese hamster, susceptible to SARS-CoV infection. SARS-CoV could propagate effectively and sustain high levels for 1 wk in animal lungs. All animals were protected from SARS-CoV infection in preventive settings. Further, when used therapeutically this antibody led to an approximately 4-log(10) decrease in viral burden in infected animal lungs. The pathological changes in lungs correlated closely with the dose of antibody administered. The excellent preventive and therapeutic roles of equine anti-SARS-CoV F(ab')(2) in several animal models, including the novel Chinese hamster model described in this study, have provided exciting data concerning its potential clinical study.