Conceptual evolution in Alzheimer's disease: implications for understanding the clinical phenotype of progressive neurodegenerative disease.
Conceptual evolution in Alzheimer's disease: implications for understanding the clinical phenotype of progressive neurodegenerative disease.
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DOI：
10.3233/jad-2010-1237
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Carr SA
中科院分区：
文献类型：
--
作者：
Jicha GA;Carr SA
在过去的几十年里，我们对阿尔茨海默病（AD）的理解已经从痴呆状态下的正常与AD的二分法概念演变为更准确和完整地理解AD作为一种进行性疾病，其临床，生物学和病理学特征沿着从正常到终末期疾病的连续体。整合我们对AD的临床、生物学和病理学特征之间的关系和相互作用的理解，可能允许在甚至临床前、完全无症状的疾病阶段识别AD。本文综述了AD的临床分期，包括流行病学、疾病分期诊断的历史演变、认知/神经心理学特征、精神/行为表现和功能下降，我们对AD发病机制的生物学过程有了进一步的了解，相关文章对此进行了详细描述。
Over the past several decades our understanding of Alzheimer’s disease (AD) has seen an evolution from the dichotomous concept of normal versus AD in the dementia state to a more accurate and complete appreciation of AD as a progressive disorder with clinical, biological, and pathological features occurring along a continuum from normal to end-stage disease. Integrating our understanding of the relationships and interplay between the clinical, biological, and pathological features of AD may allow the identification of AD at even preclinical, completely asymptomatic stages of the disease. This review attempts to summarize the clinical stages of AD in terms of epidemiology, historical evolution of disease stage diagnoses, cognitive/neuropsychologic features, psychiatric/behavioral manifestations, and functional decline in the context of our developing understanding of the biological processes responsible for the pathogenesis of AD described in detail in the accompanying articles.