Chromosome 4q25, microsomal transfer protein gene, and human longevity: Novel data and a meta-analysis of association studies
Chromosome 4q25, microsomal transfer protein gene, and human longevity: Novel data and a meta-analysis of association studies
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DOI：
10.1093/gerona/61.4.355
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发表时间：
2006-04-01
影响因子：
5.1
通讯作者：
Slagboom, PE
中科院分区：
文献类型：
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作者：
Beekman, M;Blauw, GJ;Slagboom, PE
最近，染色体4 q25与异常的人类寿命相关，并且位置候选微粒体转移蛋白（MTP）基因的单倍型与美国高加索人的表型相关。我们调查了在莱顿长寿研究的164个90岁同胞中是否可以检测到与4 q25的连锁。此外，我们比较了莱顿长寿研究（379名90岁以上老人，525名他们的后代，251名他们后代的伴侣）和莱顿85岁以上研究（655名90岁以上老人和244名年轻对照）中MTP-493 G/T和Q95 H等位基因和单倍型频率。后一研究人群至少随访7年，提供了使用纵向数据进行前瞻性分析的机会。我们既没有发现证据表明4 q25的连锁，也没有发现MTP基因座与90岁以上个体的寿命相关。对所有先前研究的荟萃分析表明，美国白人的关联可能源于美国对照人群的混合，而不是基因座的遗传效应。
Recently, chromosome 4q25 was linked to exceptional human longevity, and a haplotype of the positional candidate microsomal transfer protein (MTP) gene was associated to the phenotype in U.S. Caucasians, We investigated whether linkage to 4q25 could be detected in 164 nonagenarian sibships of the Leiden Longevity Study. Additionally, we compared the MTP -493G/T and Q95H allele and haplotype frequencies in the Leiden Longevity Study (379 nonagenarians, 525 of their offspring, and 251 partners of their offspring) and in the Leiden 85-Plus Study (655 octogenarians and 244 young controls). The latter study population was followed for at least 7 years, providing the opportunity to perform also prospective analyses using the longitudinal data. We found neither evidence for linkage at 4q25 nor association of the MTP locus with longevity in nonagenarian individuals. Meta-analyses of all previous studies implied that the association in U.S. Caucasians may have its source in admixture of the U.S. control Population rather than in the genetic effect of the locus oil exceptional longevity.