Microdosimetric measurements and estimation of human cell survival for heavy-ion beams
Microdosimetric measurements and estimation of human cell survival for heavy-ion beams
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DOI：
10.1667/rr0536.1
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发表时间：
2006-10-01
影响因子：
3.4
通讯作者：
Shinoda, Hiroshi
中科院分区：
文献类型：
--
作者：
Kase, Yuki;Kanai, Tatsuaki;Shinoda, Hiroshi
用球壁组织等效正比计数器测量了高能光子和质子、氦、碳、霓虹、硅和铁离子(LET=0.5-880keV/µm)在塑料模体中不同深度的微剂量谱。在相同的条件下，也得到了人肿瘤细胞的存活曲线。然后将存活曲线与基于每个细胞系的光谱和生物学参数的微剂量学模型估计的存活曲线进行比较。具有固定β值的线性二次模型的估计项重现了LET小于450keV/mum的离子束的细胞辐照实验结果，但在远峰附近区域除外。(C)2006年由辐射研究学会提供
The microdosimetric spectra for high-energy beams of photons and proton, helium, carbon, neon, silicon and iron ions (LET = 0.5-880 keV/mu m) were measured with a spherical-walled tissue-equivalent proportional counter at various depths in a plastic phantom. Survival curves for human tumor cells were also obtained under the same conditions. Then the survival curves were compared with those estimated by a microdosimetric model based on the spectra and the biological parameters for each cell line. The estimated a terms of the liner-quadratic model with a fixed beta value reproduced the experimental results for cell irradiation for ion beams with LETs of less than 450 keV/mu m, except in the region near the distal peak. (c) 2006 by Radiation Research Society