Lewis base activation of lewis acids: Development of a Lewis base catalyzed selenolactonization
Lewis base activation of lewis acids: Development of a Lewis base catalyzed selenolactonization
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DOI：
10.1021/ol701617d
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发表时间：
2007-09-13
期刊：
影响因子：
5.2
通讯作者：
Collins, William R.
中科院分区：
文献类型：
--
作者：
Denmark, Scott E.;Collins, William R.
将Lewis酸的Lewis碱活化的概念应用于硒内酯反应。通过使用亚化学计量的带有“软”施主原子(S，Se，P)的Lewis碱，可以看到背景反应的显著速率增强。初步的机理研究揭示了催化剂的休眠状态以及弱Bronsted酸助剂的意义。
The concept of Lewis base activation of Lewis acids has been applied to the selenolactonization reaction. Through the use of substoichiometric amounts of Lewis bases with "soft" donor atoms (S, Se, P) significant rate enhancements over the background reaction are seen. Preliminary mechanistic investigations have revealed the resting state of the catalyst as well as the significance of a weak Bronsted acid promoter.