Cellular origin and developmental program of coronary angiogenesis.
Cellular origin and developmental program of coronary angiogenesis.
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DOI：
10.1161/circresaha.116.305097
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发表时间：
2015-01-30
影响因子：
20.1
通讯作者：
Zhou B
中科院分区：
文献类型：
--
作者：
Tian X;Pu WT;Zhou B
冠状动脉疾病会导致急性心肌梗塞和心力衰竭。识别冠状血管祖细胞及其发育程序可以激发心脏病的新型再生治疗方法。冠状血管的发育起源一直笼罩在神秘之中，并且争论了几十年。最近对心内膜、心外膜和静脉窦内冠状血管祖细胞的鉴定为这个问题提供了新的见解。此外，在阐明协调冠状动脉发育的细胞和分子程序方面也取得了重大进展。建立足够的血管供应将是心脏再生策略的重要组成部分，这些发现为治疗性心脏血运重建提出了令人兴奋的新策略。
Coronary artery disease causes acute myocardial infarction and heart failure. Identifying coronary vascular progenitors and their developmental program could inspire novel regenerative treatments for cardiac diseases. The developmental origins of the coronary vessels have been shrouded in mystery and debated for several decades. Recent identification of progenitors for coronary vessels within the endocardium, epicardium and sinus venosus provides new insights into this question. In addition, significant progress has been achieved in elucidating the cellular and molecular programs that orchestrate coronary artery development. Establishing adequate vascular supply will be an essential component of cardiac regenerative strategies, and these findings raise exciting new strategies for therapeutic cardiac revascularization.