Characteristics of patients who die of necrotizing enterocolitis
Characteristics of patients who die of necrotizing enterocolitis
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DOI：
10.1038/jp.2011.65
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发表时间：
2012-03-01
影响因子：
2.9
通讯作者：
Spitzer, A. R.
中科院分区：
文献类型：
--
作者：
Clark, R. H.;Gordon, P.;Spitzer, A. R.
目的：坏死性小肠结肠炎（NEC）在入住重症监护病房的婴儿中具有较高的发病率和死亡率。与死亡率和严重表现相关的因素仍知之甚少。我们的目的是描述与NEC婴儿死亡率相关的因素，并量化严重表现对NEC婴儿死亡率的影响程度。在数据分析之前，将灾难性NEC定义为在诊断后7天内导致死亡的NEC。
研究设计：我们对Pediatrix临床数据仓库（1997年至2009年，n = 560227）进行了回顾性研究，以比较NEC存活婴儿和死亡婴儿的人口统计学、治疗和结局特征。通过双变量和多变量分析检验相关性。
结果：我们比较了5594名被诊断为NEC且出院回家的婴儿和1505名被诊断为NEC且死亡的婴儿。在多变量分析中，与死亡相关的因素（P
Objective: Necrotizing enterocolitis (NEC) is associated with high morbidity and mortality among infants admitted for intensive care. The factors associated with mortality and catastrophic presentation remain poorly understood. Our objective was to describe the factors associated with mortality in infants with NEC and to quantify the degree to which catastrophic presentation contributes to mortality in infants with NEC. Catastrophic NEC was defined before data analysis as NEC that led to death within 7 days of diagnosis.Study Design: We performed a retrospective review of the Pediatrix's Clinical Data Warehouse (1997 to 2009, n=560,227) to compare the demographic, therapeutic and outcome characteristics of infants who survived NEC vs those who died. Associations were tested by bivariate and multivariate analysis.Result: We compared the 5594 infants diagnosed with NEC and who were discharged home with 1505 infants diagnosed with NEC who died. In multivariate analysis, the factors associated with death (P