THE EMBRYONIC-CELL LINEAGE OF THE NEMATODE CAENORHABDITIS-ELEGANS
THE EMBRYONIC-CELL LINEAGE OF THE NEMATODE CAENORHABDITIS-ELEGANS
复制标题
DOI：
10.1016/0012-1606(83)90201-4
复制
发表时间：
1983-01-01
影响因子：
2.7
通讯作者：
THOMSON, JN
中科院分区：
文献类型：
--
作者：
SULSTON, JE;SCHIERENBERG, E;THOMSON, JN
秀丽隐杆线虫的胚胎细胞谱系从受精卵到新孵化的幼虫进行了追踪，结果是现在知道了这种生物的整个细胞谱系。在胚胎发生过程中产生671个细胞；在雌雄同体中，其中113个细胞（雄性111个）经历程序性死亡，其余细胞要么最终分化，要么成为胚胎后胚细胞。胚胎谱系是高度不变的，它所产生的细胞的命运也是如此。尽管细胞血统与细胞命运之间存在着固定的关系，但它们之间的相关性却缺乏明显的规律。因此，尽管大多数神经元来自胚胎外胚层，但也有一些是由中胚层产生的，少数是肌肉的姐妹细胞；再次强调，线性边界不一定与功能边界一致。细胞消融实验（以及先前的细胞分离实验）证明至少在胚胎发生的某些部分存在大量的细胞自主性。细胞谱系本身在决定细胞命运方面起着重要作用。讨论了体壁重复单元（部分片段）的起源、各种对称序列的产生、谱系的亚谱系分析及其进化意义。
The embryonic cell lineage of C. elegans was traced from zygote to newly hatched larva, with the result that the entire cell lineage of this organism is now known. During embryogenesis 671 cells are generated; in the hermaphrodite 113 of these (in the male 111) undergo programmed death and the remainder either differentiate terminally or become postembryonic blast cells. The embryonic lineage is highly invariant, as are the fates of the cells to which it gives rise. In spite of the fixed relationship between cell ancestry and cell fate, the correlation between them lacks much obvious pattern. Thus, although most neurons arise from the embryonic ectoderm, some are produced by the mesoderm and a few are sisters to muscles; again, lineal boundaries do not necessarily coincide with functional boundaries. Cell ablation experiments (and previous cell isolation experiments) demonstrate substantial cell autonomy in at least some sections of embryogenesis. The cell lineage itself plays an important role in determining cell fate. The origin of the repeat units (partial segments) in the body wall, the generation of the various orders of symmetry, the analysis of the lineage in terms of sublineages and evolutionary implications are discussed.