Mercaptocarborane-Capped Gold Nanoparticles: Electron Pools and Ion Traps with Switchable Hydrophilicity
Mercaptocarborane-Capped Gold Nanoparticles: Electron Pools and Ion Traps with Switchable Hydrophilicity
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DOI：
10.1021/ja203367h
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发表时间：
2012-01-11
影响因子：
15
通讯作者：
Vinas, Clara
中科院分区：
文献类型：
--
作者：
Cioran, Ana M.;Musteti, Ana D.;Vinas, Clara
一种简单的单相法制备钙钛矿。介绍了巯基碳硼烷配体包覆的2 nm金纳米粒子。得到的单层保护簇（MPC）表现出氧化还原依赖的溶解度和容易的水和非极性溶剂之间的相转移取决于存储在金属核和配体壳中的电子和离子电荷，分别。颗粒和它们的性质已经通过在扫描透射电子显微镜中的高角度环形暗场成像、元素分析、离心粒度测定、UV-vis和FTIR光谱和热重分析以及通过H-1、B-11和Li-7 NMR光谱表征。通过TEM研究了HeLa细胞对MPC的细胞摄取，并通过共聚焦荧光显微镜评价了细胞内活性氧的随后产生。这些MPC定性地显示出显著的毒性和渗透到大多数细胞隔室中的能力，具有最终驻留在膜内的强烈倾向。在催化，电催化和生物医学的应用设想。
A simple single-phase method for the preparation of ca. 2 nm gold nanoparticles capped with mercaptocarborane ligands is introduced. The resultant monolayer protected clusters (MPCs) exhibit redox-dependent solubility and readily phase transfer between water and nonpolar solvents depending on the electronic and ionic charge stored in the metal core and in the ligand shell, respectively. The particles and their properties have been characterized by high angle annular dark field imaging in a scanning transmission electron microscope, elemental analysis, centrifugal particle sizing, UV-vis and FTIR spectroscopy, and thermogravimetric analysis and by H-1, B-11, and Li-7 NMR spectroscopy. Cellular uptake of the MPCs by HeLa cells has been studied by TEM, and the subsequent generation of reactive oxygen species inside the cells has been evaluated by confocal fluorescence microscopy. These MPCs qualitatively showed significant toxicity and the ability to penetrate into most cell compartments with a strong tendency of finally residing inside membranes. Applications in catalysis, electrocatalysis, and biomedicine are envisaged.