Drug independence and the curability of cancer by combination chemotherapy.
Drug independence and the curability of cancer by combination chemotherapy.
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DOI：
10.1016/j.trecan.2022.06.009
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发表时间：
2022-11
期刊：
影响因子：
18.4
通讯作者：
Palmer AC
中科院分区：
文献类型：
--
作者：
Pomeroy AE;Schmidt EV;Sorger PK;Palmer AC
Combination chemotherapy can cure certain leukemias and lymphomas, but most solid cancers are only curable at early stages. We review quantitative principles that explain the benefits of combining independently active cancer therapies in both settings. Understanding the mechanistic principles underlying curative treatments, including those developed many decades ago, is valuable for improving future combination therapies. We discuss contemporary evidence for long-established but currently neglected ideas of how combination therapy overcomes tumor heterogeneity. We show that a unified model of inter-patient and intra-tumor heterogeneity describes historical progress in the treatment of pediatric Acute Lymphocytic Leukemia (ALL), in which increasingly intensive combination regimens ultimately achieved high cure rates. We also describe three distinct aspects of drug independence that apply at different biological scales. The ability of these principles to quantitatively explain curative regimens suggests that supra-additive (synergistic) drug interactions are not required for successful combination therapy.
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影响因子：
2.2
作者：
Chen, Cong;Liu, Fang;Schmidt, Emmett V.
通讯作者：
Schmidt, Emmett V.
影响因子：
7.7
作者：
Bozic I;Reiter JG;Allen B;Antal T;Chatterjee K;Shah P;Moon YS;Yaqubie A;Kelly N;Le DT;Lipson EJ;Chapman PB;Diaz LA Jr;Vogelstein B;Nowak MA
通讯作者：
Nowak MA
影响因子：
82.9
作者：
Hata AN;Niederst MJ;Archibald HL;Gomez-Caraballo M;Siddiqui FM;Mulvey HE;Maruvka YE;Ji F;Bhang HE;Krishnamurthy Radhakrishna V;Siravegna G;Hu H;Raoof S;Lockerman E;Kalsy A;Lee D;Keating CL;Ruddy DA;Damon LJ;Crystal AS;Costa C;Piotrowska Z;Bardelli A;Iafrate AJ;Sadreyev RI;Stegmeier F;Getz G;Sequist LV;Faber AC;Engelman JA
通讯作者：
Engelman JA
DOI：
10.1182/blood.v26.5.642.642
发表时间：
1965-01-01
期刊：
BLOOD-THE JOURNAL OF HEMATOLOGY
影响因子：
--
作者：
FREI, E;KARON, M;MOON, JH
通讯作者：
MOON, JH
影响因子：
16.6
作者：
Ling A;Huang RS
通讯作者：
Huang RS