Endogenous carcinogenesis: molecular oncology into the twenty-first century--presidential address.
Endogenous carcinogenesis: molecular oncology into the twenty-first century--presidential address.
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作者：
Lawrence A. Loeb
在这篇文章中，我将考虑致癌的一个方面，需要进一步深入研究，因为它可能是人类癌症的一个主要原因。我指的是Damoclean的可能性，即某些正常的内源性细胞过程具有内在的诱变性，这种内在的突变是某些人类癌症的病因和发病机制中的一个重要因素。此外，我还将前瞻性地考虑分子生物学对癌症研究的影响。我们在分子和原子水平上确定基因组成的能力可能会从根本上改变癌症研究的许多方面。分子生物学的新技术不仅突显了我们在理解正常细胞和癌细胞之间差异方面的严重缺陷，还给了我们信心，相信新的、更深层次的、更基本的见解很快就会掌握在我们手中。我很高兴地报告，我们协会采取了新的举措，将分子生物学的最新进展纳入癌症研究人员的研究范围，从而将成为将分子肿瘤学带入21世纪的主要促进者。
In this paper I will consider an aspect of carcinogenesis that needs further in-depth study because it could be a major cause of human cancers. I am referring to the Damoclean possibility that certain normal endogenous cellular processes are inher ently mutagenic and that this intrinsic mutagenesis is a signif icant factor in the etiology and pathogenesis of some human cancers. Moreover, I will prospectively consider the impact of molecular biology on cancer research. Our ability to determine the composition of genes at the molecular and atomic levels is likely to change radically many facets of cancer research. New techniques in molecular biology not only have highlighted critical deficiencies in our understanding of the differences between normal and cancer cells but also have lent us confidence that new and deeper, more fundamental insights will soon be within our grasp. I am pleased to report that our Association has taken new initiatives to incorporate recent advances in molecular biology into the purview of cancer researchers and thereby will be a leading facilitator of the transport of molecular oncology into the 21st century.