Determinant and outcome of early diagnosis of HIV infection among HIV-exposed infants in southwest Ethiopia.
Determinant and outcome of early diagnosis of HIV infection among HIV-exposed infants in southwest Ethiopia.
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DOI：
10.1186/1756-0500-7-309
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发表时间：
2014-05-22
影响因子：
1.8
通讯作者：
Makonnen M
中科院分区：
文献类型：
--
作者：
Derebe G;Biadgilign S;Trivelli M;Hundessa G;Robi ZD;Gebre-Mariam M;Makonnen M
预防人类免疫缺陷病毒感染（艾滋病毒）的母婴传播（PMTCT）是过去十年来获得性免疫缺陷综合症（艾滋病）应对措施的一个根本性进展。一些国家在努力预防艾滋病毒母婴传播方面取得了长足进展。本研究的目的是评估埃塞俄比亚西南部艾滋病毒暴露的婴儿中艾滋病毒感染的早期诊断的决定因素和结果。在一家医院进行了一项基于机构的回顾性队列研究。对参加该项目的艾滋病毒暴露婴儿及其母亲的医疗记录进行了审查。使用SPSS 20 for Windows进行数据输入和分析。共有426对暴露于艾滋病毒的母婴对，其中母亲和婴儿都接受了最低限度的抗逆转录病毒干预，以防止母婴传播。254名（59.6%）母亲接受过产前保健。在所有参与者中，234名（54.9%）母亲在ANC期间没有接受任何预防母婴传播的预防，而只有104名（24.4%）接受抗逆转录病毒（ART）作为预防母婴传播的预防，163名（38.3%）声称没有观察到任何婴儿预防母婴传播的干预措施，而135名（31.7%）婴儿接受单剂量NVP + AZT。约385名（90.4%）婴儿在最终感染状态下未被感染。那些没有参加产前护理随访的母亲、混合喂养和补充喂养的婴儿、断奶的婴儿以及世卫组织临床III期和IV期的母亲更有可能生下艾滋病毒血清阳性婴儿。这项研究表明，385名（90.4%）婴儿在最终感染状态下未被感染。因此，建议鼓励孕妇在怀孕期间到保健设施就诊，重点是提供专门的母乳喂养咨询和宣传，并对感染艾滋病毒的孕妇及早开始抗逆转录病毒治疗。
Preventing mother-to-child transmission (PMTCT) of human immunodeficiency virus infection (HIV) has been a fundamental advancement in the acquired immunodeficiency syndrome (AIDS) response for the past decade. Several countries have made great strides in the efforts to prevent HIV through mother-to-child transmission. The objective of this study is to assess the determinant and outcome of early diagnosis of HIV infection among HIV-exposed infants in southwest Ethiopia. An institutional based retrospective cohort study was conducted in a hospital. Medical records of HIV-exposed infants and their mothers enrolled into the program were reviewed. Data entry and analysis was carried out using SPSS version 20 for Windows. A total of 426 HIV exposed infant-mother pairs where both mother and infants received a minimum ARV intervention for PMTCT were included in the study. Two hundred fifty-four (59.6%) of mothers had attended antenatal care (ANC). Of all participants, 234(54.9%) mothers did not receive any PMTCT prophylaxis during ANC, while only 104(24.4) received antiretroviral (ART) as PMTCT prophylaxis and 163(38.3%) claimed that did not observe any infant PMTCT interventions while 135(31.7%) of the infants received single-dose NVP + AZT. About 385(90.4%) infants were not infected at their final infection status. Those mothers who did not attended ANC follow-up, infants on mixed and complementary feeding and infants weaned off and mothers who were in WHO clinical stage III and IV were more likely to have HIV sero positive infant. This study showed that 385(90.4%) of the infants were not infected at their final infection status. Therefore, encouraging pregnant women to visit health facilities during their course of pregnancy, focusing on exclusive breast feeding counseling and promotion, and early initiation of antiretroviral treatment to HIV infected pregnant women are recommend.