High seroprevalence of hantavirus infection on the Azuero peninsula of Panama
High seroprevalence of hantavirus infection on the Azuero peninsula of Panama
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DOI：
10.4269/ajtmh.2004.70.682
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发表时间：
2004-06-01
影响因子：
3.3
通讯作者：
Koster, F
中科院分区：
文献类型：
--
作者：
Armien, B;Pascale, JM;Koster, F
1999年底和2000年在巴拿马的阿苏埃罗半岛记录了中美洲首次汉坦病毒肺综合征（HPS）暴发。逆转录-聚合酶链反应的证据表明，只有Choclo病毒的症状HPS的死亡率为20%，虽然两个啮齿动物传播的汉坦病毒（Choclo病毒和Calabazo病毒）被确定在peridomestic栖息地。在病例家庭周围进行的社区血清调查发现，血清阳性率高达30%，是除巴拉圭西部以外美洲最高的。我们在此报告对四个社区的1 346名成人和儿童进行了基于人口的血清调查，三个社区位于阿苏埃罗半岛，一个社区位于邻近的巴拿马中部。总体血清阳性率范围为33.2%，在从事农业和渔业的人口在卡哈斯岛，16.3%和21.2%，在两个大陆农业社区，在巴拿马中部的3.1%，与适度的男性优势为1.2：1。9%的4-10岁儿童血清反应呈阳性，在所有社区，血清反应阳性率随着年龄的增长而增加，在卡纳斯岛，41-50岁年龄组的血清反应阳性率最高，为52%。单因素分析确定血清阳性率和多种农业和畜牧业活动之间的相关性。然而，逐步逻辑回归模型确定只有饲养动物（牛，猪，山羊，家禽）和捕鱼作为重要的自变量。在阿苏埃罗半岛，人类感染汉坦病毒，无论是与Choclo病毒还是与Calabazo病毒结合，都很常见，但很少因类似HPS的呼吸道疾病而导致住院治疗。
The first outbreak of hantavirus pulmonary syndrome (HPS) in Central America was documented on the Azuero peninsula of Panama in late 1999 and 2000. Reverse transcriptase-polymerase chain reaction evidence implicated only Choclo virus in symptomatic HPS with a mortality rate of 20%, although two rodent-borne hantaviruses (Choclo virus and Calabazo virus) were identified in the peridomestic habitat. Neighborhood serosurveys around case households found seroprevalence rates as high as 30%, the highest in the Americas except for western Paraguay. We report here population-based serosurveys for 1,346 adults and children in four communities, three on the Azuero peninsula and one in adjacent central Panama. Overall seroprevalence ranged from 33.2% in a population engaged in farming and fishing on Isla de Cahas, to 16.3% and 21.2% in two mainland agricultural communities, to 3.1% in central Panama, with a modest male predominance of 1.2:1. Nine percent of children 4-10 years old were seropositive, and seroprevalence increased with age in all communities, with highest levels of 52% in those 41-50 years old cohort on Isla de Canas. Univariate analysis identified correlations between seroprevalence and multiple agricultural and animal husbandry activities. However, stepwise logistic regression models identified only raising animals (cows, pigs, goats, poultry) and fishing as significant independent variables. Human infection with hantavirus on the Azuero peninsula, either with Choclo virus or combined with Calabazo virus, is frequent but rarely results in hospitalization due to respiratory illnesses resembling HPS.