THE USE OF A COLLAGEN SHEET AS A DISC REPLACEMENT IN THE RABBIT TEMPOROMANDIBULAR-JOINT
THE USE OF A COLLAGEN SHEET AS A DISC REPLACEMENT IN THE RABBIT TEMPOROMANDIBULAR-JOINT
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DOI：
10.1016/0278-2391(95)90066-7
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发表时间：
1995-05-01
影响因子：
1.9
通讯作者：
MCDONNELL, EJ
中科院分区：
文献类型：
--
作者：
FEINBERG, SE;MCDONNELL, EJ
目的：材料与方法：20只成年新西兰白色兔随机分为4组，每组5只：1）非手术对照组，2）颞下颌关节椎间盘切除术后不置换组，3）椎间盘切除术后真皮移植组，4）自体真皮移植组。椎间盘切除加胶原片置换术。每只手术动物的双侧手术相同。分别于术后2、4、8、18、36周处死家兔，将TMJ整块切除、脱钙、切片、染色进行组织学评价。在没有椎间盘置换的椎间盘切除关节中存在显著的关节破坏，真皮和胶原椎间盘置换物在第8周时均被吸收，关节面表现出软骨增生，结论：本研究表明，胶原蛋白片和真皮移植物都可以起到保护作用，并可能有助于延缓通常在椎间盘切除的TMJ关节面中看到的早期退行性变化。
Purpose: This study evaluated a biocompatible, preformed collagen sheet as a disc replacement after temporomandibular joint (TMJ) surgery in the rabbit and compared its performance with that of an autogenous dermal graft.Materials and Methods: Twenty adult New Zealand white rabbits were divided into four groups of five animals: 1) nonoperated control; 2) TMJ discectomy without replacement; 3) discectomy with dermal graft replacement; and 4) discectomy with collagen sheet replacement. Each operated animal had the same procedure bilaterally. Rabbits were killed at 2, 4, 8, 18, and 36 weeks after surgery and the TMJs were surgically removed en bloc, decalcified, sectioned, and stained for histologic evaluation,Results: There was significant articular destruction in the discectomized joints with no disc replacement, Both the dermal and collagen disc replacements were resorbed by the eighth week and the articular surfaces exhibited cartilaginous hyperplasia, which returned to near normal thickness by the 18th week.Conclusion: This study demonstrated that both a collagen sheet and a dermal graft may act in a protective capacity and may help retard early degenerative changes normally seen in the articular surfaces of discectomized TMJs.