The Changing Pathology of Lung Cancer
The Changing Pathology of Lung Cancer
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DOI：
10.1016/j.soc.2011.07.004
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发表时间：
2011-10-01
影响因子：
1.9
通讯作者：
Schraeder, Richard
中科院分区：
文献类型：
--
作者：
Fan, Zhen;Schraeder, Richard
肺癌的分类对肿瘤患者的治疗至关重要。大多数肺癌为非小细胞肺癌（NSCLC），其进一步细分为鳞状细胞癌、腺癌和大细胞癌。肺神经内分泌肿瘤可分为典型类癌、非典型类癌、小细胞癌和大细胞神经内分泌癌。特别是在非小细胞肺癌中，组织学分类和肿瘤突变分析是当今靶向治疗和个性化治疗的核心。本文讨论了目前非小细胞肺癌和肺神经内分泌肿瘤的分类诊断标准及其对肿瘤治疗的意义。
Lung cancer classification is of paramount importance in determining the treatment for oncologic patients. Most lung cancers are non-small cell lung carcinomas (NSCLC), which are further subclassified into squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Lung neuroendocrine tumors are subclassified into typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. In NSCLC in particular, the histologic classification and tumor mutation analysis are central to today's targeted therapy and personalized treatment. This article discusses the current diagnostic criteria for classification of NSCLC and lung neuroendocrine tumors and implications for oncologic treatment.