Effect of melatonin on age associated changes in guinea pig bladder function
Effect of melatonin on age associated changes in guinea pig bladder function
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DOI：
10.1016/j.juro.2006.11.071
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发表时间：
2007-04-01
影响因子：
6.6
通讯作者：
Andersson, Karl-Erik
中科院分区：
文献类型：
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作者：
Gomez-Pinilla, Pedro J.;Gomez, Maria F.;Andersson, Karl-Erik
目的：尿失禁的发病率随着年龄的增长而增加，但年龄和膀胱功能改变之间的因果关系知之甚少。这表明褪黑激素可以通过其自由基清除活性和降低氧化应激的能力来改善衰老引起的负面影响。我们研究了膀胱功能的变化引起的老化和褪黑激素治疗年龄相关的膀胱disorders.Materials和方法的可能的好处：膀胱功能进行了评估，使用膀胱测压在清醒的，自由活动的雌性豚鼠。根据年龄将动物分组为青年（4个月大）和老年（18至20个月大）。一组衰老动物用2.5 mg kg（-1）day（-1）褪黑激素治疗21 day.Results：衰老导致逼尿肌活动增加，表现为排尿间隔缩短、膀胱容量减少和充盈期自发收缩。在排尿阶段，老年动物表现出较低的排尿压力比年轻人。褪黑激素抵消了膀胱测压的变化，在衰老的动物和恢复排尿参数的年轻adulth.Conclusions：这些结果表明，在豚鼠老化诱导逼尿肌过度活动。褪黑激素治疗改善年龄引起的膀胱功能变化。如果类似的效果可以在人类身上得到证实，褪黑激素治疗可能是一种新的方法，以减少年龄相关的膀胱疾病的影响。
Purpose: The incidence of urinary incontinence increases with age but the cause and effect relationship between aging and altered bladder function is poorly understood. It was suggested that melatonin can ameliorate negative effects induced by aging by its free radical scavenging activity and its ability to decrease oxidative stress. We investigated the changes in bladder function evoked by aging and the possible benefits of melatonin treatment on age related bladder disturbances.Materials and Methods: Bladder function was assessed using cystometry in conscious, freely moving female guinea pigs. Animals were grouped according to age as young adults (4 months old) and senescents (18 to 20 months old). A group of senescent animals were treated with 2.5 mg kg(-1) day(-1) melatonin for 21 days.Results: Aging led to increased detrusor activity, as demonstrated by short micturition intervals, decreased bladder capacity and spontaneous contractions during the filling phase. During the voiding phase aged animals showed lower micturition pressures than young adults. Melatonin counteracted the cystometric changes in senescent animals and restored micturition parameters to those of young adults.Conclusions: These results show that in guinea pigs aging induces detrusor overactivity. Melatonin treatment improved age induced changes in bladder function. If similar effects can be demonstrated in humans, melatonin treatment may be a new approach to decrease the impact of age related bladder disorders.