From specific gene regulation to genomic networks:: a global analysis of transcriptional regulation in Escherichia coli
From specific gene regulation to genomic networks:: a global analysis of transcriptional regulation in Escherichia coli
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DOI：
10.1002/(sici)1521-1878(199805)20:5
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发表时间：
1998-05-01
期刊：
影响因子：
4
通讯作者：
Collado-Vides, J
中科院分区：
文献类型：
--
作者：
Thieffry, D;Huerta, AM;Collado-Vides, J
由于在过去的几十年里，大量涉及基因调控的分子机制已经被描述，现在有可能解决有关基因调控网络的全球结构的问题，至少在一些最具特征的生物体的情况下。本文在现有数据的基础上，对大肠杆菌的转录调控进行了全局表征，通过分析特定调控蛋白调控的基因数量分布，以及特定调控基因调控的基因数量分布，来评价相应网络的连通性。所发现的平均连通性（在2到3之间）显示出一个相当松散的互联结构。特别强调的是相互作用的循环序列（“电路”），因为他们的临界动力学性质。只发现了单元件电路，其中负自动调节是主导结构。这些整体特性讨论了几个相关的理论方法，以及在生理和进化方面的考虑。生物学报，1998。(C) 1998 John Wiley & Sons公司
Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms. This paper presents a global characterization of the transcriptional regulation in Escherichia coli on the basis of the current data, The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of genes regulated by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions ("circuits") because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20.433-440, 1998. (C) 1998 John Wiley & Sons, Inc.