Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events - A prospective assessment with MRI - Initial results
Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events - A prospective assessment with MRI - Initial results
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DOI：
10.1161/01.str.0000204638.91099.91
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发表时间：
2006-03-01
期刊：
影响因子：
8.3
通讯作者：
Hatsukami, TS
中科院分区：
文献类型：
--
作者：
Takaya, N;Yuan, C;Hatsukami, TS
背景和目的-MRI能够以良好的准确性和再现性定量颈动脉斑块的大小和组成，并提供了一个机会，前瞻性地检查斑块特征和随后的脑血管事件之间的关系。我们测试的假设，颈动脉斑块的特点，通过MRI评估，是未来同侧脑血管events. Methods的预测，共有154个连续的主题谁最初有一个无症状的50%至79%的颈动脉狭窄超声随访>= 12个月被列入本研究。基线时进行多对比加权颈动脉核磁共振成像，每3个月对参与者进行一次临床随访，以识别脑血管事件的症状。结果-在平均38.2个月的随访期内，12起颈动脉脑血管事件发生在指数颈动脉的同侧。考克斯回归分析表明，基线MRI识别的以下斑块特征与随访期间的后续症状之间存在显著相关性：存在薄或破裂的纤维帽（风险比，17.0; P
Background and Purpose-MRI is able to quantify carotid plaque size and composition with good accuracy and reproducibility and provides an opportunity to prospectively examine the relationship between plaque features and subsequent cerebrovascular events. We tested the hypothesis that the characteristics of carotid plaque, as assessed by MRI, are possible predictors of future ipsilateral cerebrovascular events.Methods-A total of 154 consecutive subjects who initially had an asymptomatic 50% to 79% carotid stenosis by ultrasound with >= 12 months of follow-up were included in this study. Multicontrast- weighted carotid MRIs were performed at baseline, and participants were followed clinically every 3 months to identify symptoms of cerebrovascular events.Results-Over a mean follow-up period of 38.2 months, 12 carotid cerebrovascular events occurred ipsilateral to the index carotid artery. Cox regression analysis demonstrated a significant association between baseline MRI identification of the following plaque characteristics and subsequent symptoms during follow-up: presence of a thin or ruptured fibrous cap (hazard ratio, 17.0; P