Benzoylthiourea-Pyrrolidine as Another Bifunctional Organocatalyst: Highly Enantioselective Michael Addition of Cyclohexanone to Nitroolefins
Benzoylthiourea-Pyrrolidine as Another Bifunctional Organocatalyst: Highly Enantioselective Michael Addition of Cyclohexanone to Nitroolefins
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苯甲酰硫脲-吡咯烷作为另一种双功能有机催化剂：环己酮与硝基烯烃的高对映选择性迈克尔加成
DOI：
10.1002/ejoc.201300225
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发表时间：
2013-05-01
影响因子：
2.8
通讯作者：
Li, Qing-shan
中科院分区：
文献类型：
--
作者：
Ban, Shu-rong;Zhu, Xi-xia;Li, Qing-shan
在有机催化剂1（10摩尔%）和2，4-二氯苯甲酸（10摩尔%）的存在下，环己酮与硝基苯乙烯的不对称迈克尔加成反应在温和条件下以中等至良好的产率、高非对映选择性（高达>99：1 dr）和高对映选择性（高达> 99%ee）得到相应的有合成价值的γ-硝基酮。
Asymmetric Michael addition of cyclohexanone to nitrostyrenes in the presence of organocatalyst 1 (10 mol-%) and 2,4-dichlorobenzoic acid (10 mol-%) afforded the corresponding synthetically valuable gamma-nitroketones in moderate to good yields with high diastereoselectivities (up to >99:1 dr) and high enantioselectivities (up to >99% ee) under mild conditions.