Autophagy in Reproduction
Autophagy in Reproduction
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DOI：
10.1007/978-981-15-0602-4_21
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Li, Wei
中科院分区：
文献类型：
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作者：
Gao, Hui;Khawar, Muhammad Babar;Li, Wei
自噬是一种重要的降解/再循环途径，在维持细胞稳态、决定细胞命运和生殖发育中起着重要作用。在生殖过程中，精子和卵子分别由雄性和雌性生殖细胞减数分裂过程产生的特化单倍体配子融合形成一个新的受精卵，通过胚胎发生和母胎串扰发育成胎儿。近年来的研究证明，自噬在生殖过程中起着关键的调节作用，自噬过程受阻可能导致生殖异常甚至不育。本文综述了近年来自噬在动物和植物的生殖过程中的功能作用，如精子发生、卵泡发生、受精、胚胎发生和母胎串扰。
Autophagy, a major degradation/recycling pathway, plays an essential role in cellular homeostasis maintenance, cell fate decision, and reproductive development. During reproduction, sperms and eggs, the specialized haploid gametes produced by the meiotic process of the germ cells in male and female respectively, are fused to form a new zygote that develops into fetus through embryogenesis and maternal-fetal crosstalk. Researches carried out in the past few years have proved that autophagy plays a key role in the regulation of reproduction process, and blockage of autophagy process likely contributes to reproductive abnormalities and even infertility. Here we summerize the recent progress in exploring the functional roles of autophagy in reproductive processes, such as spermatogenesis, folliculogenesis, fertilization, embryogenesis, and maternal-fetal crosstalk, in both animals and plants.