Modelling the influence of endothelial heterogeneity on the progression of arterial disease: application to abdominal aortic aneurysm evolution
Modelling the influence of endothelial heterogeneity on the progression of arterial disease: application to abdominal aortic aneurysm evolution
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DOI：
10.1002/cnm.2620
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发表时间：
2014-05-01
影响因子：
2.1
通讯作者：
Watton, P. N.
中科院分区：
文献类型：
--
作者：
Aparicio, P.;Mandaltsi, A.;Watton, P. N.
我们建立了一个流体-固体生长的计算框架来模拟动脉瘤的演变。动脉壁的真实结构模型被集成到脉管系统的患者特定几何结构中。这使得从刚性壁计算流体动力学分析获得的血液动力学刺激的生理代表性分布能够与生长和重塑算法相关联。此外，准静态结构分析量化了动脉壁的周期性变形，使得胶原蛋白生长和重塑可以明确地与血管细胞的周期性变形相关联。为了模拟动脉瘤演变，通过壁剪切应力（WSS）降低至稳态阈值以下来驱动弹性蛋白降解。鉴于内皮细胞表现出空间和时间的异质性，我们提出了一种新的方法来定义稳态WSS阈值：我们允许它们在空间和时间上是异质的。我们说明了应用这种新的流体-固体生长框架模型腹主动脉瘤（AAA）的演变，并研究如何影响的WSS稳态阈值的定义影响AAA的进展。我们的结论是，更好地理解和建模的内皮异质性是很重要的动脉瘤的发展，更普遍的是，其他血管疾病的血液动力学刺激发挥了重要作用。版权所有（c）2014约翰威利父子有限公司
We sophisticate a fluid-solid growth computational framework for modelling aneurysm evolution. A realistic structural model of the arterial wall is integrated into a patient-specific geometry of the vasculature. This enables physiologically representative distributions of haemodynamic stimuli, obtained from a rigid-wall computational fluid dynamics analysis, to be linked to growth and remodelling algorithms. Additionally, a quasistatic structural analysis quantifies the cyclic deformation of the arterial wall so that collagen growth and remodelling can be explicitly linked to the cyclic deformation of vascular cells. To simulate aneurysm evolution, degradation of elastin is driven by reductions in wall shear stress (WSS) below homeostatic thresholds. Given that the endothelium exhibits spatial and temporal heterogeneity, we propose a novel approach to define the homeostatic WSS thresholds: We allow them to be spatially and temporally heterogeneous. We illustrate the application of this novel fluid-solid growth framework to model abdominal aortic aneurysm (AAA) evolution and to examine how the influence of the definition of the WSS homeostatic threshold influences AAA progression. We conclude that improved understanding and modelling of the endothelial heterogeneity is important for modelling aneurysm evolution and, more generally, other vascular diseases where haemodynamic stimuli play an important role. Copyright (c) 2014 John Wiley & Sons, Ltd.