Correlation between chemical composition and antifungal activity of the essential oils of eight Cinnamomum species
Correlation between chemical composition and antifungal activity of the essential oils of eight Cinnamomum species
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DOI：
10.1080/13880200802055859
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发表时间：
2008-01-01
影响因子：
3.8
通讯作者：
Jamal, Jamia Azdina
中科院分区：
文献类型：
--
作者：
bin Jantan, Ibrahim;Moharam, Bushra Abdul Karim;Jamal, Jamia Azdina
从樟科8种肉桂属植物（C. pubescens Kochummen、毛萼木霉C. impressicostatum Kosterm、凹唇隐翅虫C. microphyllum Ridl.，C. scortechinii Gamb.，C. Rhyncophyllum Miq.，C. cordatum Kosterm，C. zeylanicum Blume和C. mollissimum Hook f.）对6种皮肤癣菌（红色毛癣菌、T. mentagrophytes、须毛藓T. tonsurans、犬小孢子菌（Microsporum canis）、M. gypseum和M. audouini）、一种丝状真菌（烟曲霉（Aspergillus fumigatus））和五种酵母菌（白色念珠菌（Candida albicans）、C. glabrata、光叶隐翅虫C. tropicalis、热带假丝酵母C.和新生隐球菌）。13个标准化合物的抗真菌活性，在肉桂油中的流行成分也进行了研究，在努力相关的油的有效性与油的成分。通过GC和GC-MS分析了挥发油的化学成分，大部分挥发油表现出中到强的抑菌活性。其中，C. zeylanicum对所有真菌表现出最高的活性，MIC值为0.04 - 0.63 μ g μ L-1。其他对真菌生长有较强抑制作用的油是C. cordatum和C. pubescens和C.凹肋苔属肉桂醛是肉桂树皮油中含量最高的成分。zeylanicum对所有研究的真菌显示出最强的活性。基于标准样品的测定结果，油中高水平的肉桂醛、丁香酚、香叶醇、苯甲酸苄酯和肉桂酸甲酯以及与次要组分的组合可能是油的高抗真菌活性的原因。
Fourteen essential oils hydrodistilled from eight Cinnamomum (Lauraceae) species (C. pubescens Kochummen, C. impressicostatum Kosterm, C. microphyllum Ridl., C. scortechinii Gamb., C. rhyncophyllum Miq., C. cordatum Kosterm, C. zeylanicum Blume, and C. mollissimum Hook f.) were examined for their antifungal activity against six dermatophytes (Trichophyton rubrum, T. mentagrophytes, T. tonsurans, Microsporum canis, M. gypseum, and M. audouini), one filamentous fungi (Aspergillus fumigatus), and five strains of yeasts (Candida albicans, C. glabrata, C. tropicalis, C. parapsilosis, and Crytococcus neoformans) by using the broth microdilution method. The antifungal activities of 13 standard compounds that are prevalent constituents in Cinnamomum oils were also investigated in an effort to correlate the effectiveness of the oils with those of the components of the oils. The chemical composition of the oils was analyzed by GC and GC-MS. Most of the oils showed moderate to strong activity against the fungi. Among the oils, the leaf and bark oils of C. zeylanicum showed the highest activity against all the fungi with MIC values of 0.04 to 0.63 mu g mu L-1. Other oils that gave a strong inhibition on fungal growth were the leaf oil of C. cordatum and bark and twig oils of C. pubescens and C. impressicostatum. Cinnamaldehyde, which was the most abundant component of the bark oil of C. zeylanicum, showed the strongest activity against all the fungi studied. Based on the results of the assay on standard samples, it may be that the high levels of cinnamaldehyde, eugenol, geraniol, benzyl benzoate, and methyl cinnamate in the oils and in combination with the minor components is responsible for the high antifungal activity of the oils.