One-year change in cerebral glucose metabolism in patients with Alzheimer's disease
One-year change in cerebral glucose metabolism in patients with Alzheimer's disease
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DOI：
10.1176/appi.neuropsych.16.4.488
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发表时间：
2004-09-01
影响因子：
2.9
通讯作者：
Mori, E
中科院分区：
文献类型：
--
作者：
Hirono, N;Hashimoto, M;Mori, E
作者利用[F-18]-2-氟脱氧-D-葡萄糖和正电子发射断层扫描技术，研究了轻度阿尔茨海默病（AD）患者间隔1年后局部糖代谢的变化。随着时间的推移，双侧楔前叶和后扣带回以及额叶、颞叶和顶叶皮质的葡萄糖代谢下降。这些区域的葡萄糖代谢可能是AD进展的有用指标，也是临床药物试验的有效替代结局指标。
By using [F-18]-2-fluoro-deoxy-D-glucose and positron emission tomography, the authors studied changes in regional glucose metabolism after a 1-year interval in patients with mild Alzheimer's disease (AD). Glucose metabolism declined over time in the bilateral precuneus and posterior cingulate gyri and in the frontal, temporal, and parietal cortices. Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials.