The Neurocognitive Effects of Type 1 Diabetes Mellitus in Children and Young Adults With and Without Hypoglycemia
The Neurocognitive Effects of Type 1 Diabetes Mellitus in Children and Young Adults With and Without Hypoglycemia
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DOI：
10.1007/s10882-009-9151-y
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发表时间：
2009-10-01
影响因子：
1.8
通讯作者：
Obrzut, John E.
中科院分区：
文献类型：
--
作者：
Bade-White, Priscilla A.;Obrzut, John E.
1 型糖尿病是 18 岁以下儿童和年轻人最常见的疾病之一。这种疾病的症状，包括有或没有严重低血糖的症状，会导致血糖水平异常和胰岛素水平异常。这些异常的化学水平与记忆、注意力、运动技能、视觉空间能力和执行功能的神经认知缺陷有关。本文综述了与胰岛素依赖型糖尿病对学龄儿童和年轻人的影响相关的中枢神经系统变化的现有文献。讨论了对学习的影响以及执行功能缺陷的神经生物学原因。
Type 1 Diabetes Mellitus is one of the most common illnesses found in children under the age of 18 as well as in young adults. Symptoms of this disease, including those with and without severe hypoglycemia, create abnormal blood glucose levels along with abnormal insulin levels. These abnormal chemical levels have been associated with neurocognitive deficits in memory, attention, motor skills, visuospatial abilities and executive functioning. In this paper, available literature on the central nervous system changes associated with the effects of insulin-dependent diabetes on school-aged children and young adults is reviewed. Implications for learning as well as a neurobiological cause of executive function deficits are discussed.