IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children
IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children
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DOI：
10.1016/j.cyto.2010.03.001
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发表时间：
2010-07-01
期刊：
影响因子：
3.8
通讯作者：
Fukunaga, Yoshitaka
中科院分区：
文献类型：
--
作者：
Asano, Takeshi;Ichiki, Kunihiko;Fukunaga, Yoshitaka
细菌性脑膜炎预后差，有神经系统并发症。本研究旨在探讨细菌性脑膜炎和无菌性脑膜炎患儿脑脊液中细胞因子/趋化因子网络的变化。同时测定CSF上清液中的白细胞介素（IL）-1 β、IL-2、IL-4、IL-5、IL-6、IL-7、IL-8、IL-10、IL-12、IL-13、IL-17、干扰素-γ、肿瘤坏死因子-α、粒细胞集落刺激因子、粒细胞单核细胞集落刺激因子、单核细胞趋化蛋白-1和巨噬细胞炎性蛋白-1 β。我们发现，IL-17在细菌性脑膜炎的CSF中显著升高。我们认为IL-17在细菌性脑膜炎中性粒细胞浸润CSF和神经元保护中起关键作用。(C)2010爱思唯尔有限公司版权所有。
Bacterial meningitis has a poor prognosis and neurologic complications. The present study aimed to investigate the cytokine/chemokine network in cerebrospinal fluid (CSF) from children with bacterial meningitis and aseptic meningitis. Interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, interferon-gamma, tumor necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 beta, were measured simultaneously in CSF supernatants. We found that, IL-17 was significantly elevated in CSF with bacterial meningitis. We believe that IL-17 plays a key role in neutrophil infiltration into CSF and neuronal protection in bacterial meningitis. (C) 2010 Elsevier Ltd. All rights reserved.