Mechanism of action of vasoactive intestinal polypeptide on cerebral arterioles.
Mechanism of action of vasoactive intestinal polypeptide on cerebral arterioles.
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血管活性肠多肽对脑小动脉的作用机制。
DOI：
10.1152/ajpheart.1980.239.6.h765
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Said,SI
中科院分区：
文献类型：
--
作者：
Wei,EP;Kontos,HA;Said,SI
本文研究了血管活性肠多肽（VIP）对麻醉猫脑小动脉的影响，并通过急性植入颅窗观察脑微循环。在脑表面以0.01-1.0微克/毫升剂量局部应用VIP可产生剂量相关的血管舒张，其在小动脉（< 100微米直径）和大动脉（100微米直径）上的舒张程度相同。最大膨胀平均为对照直径的20%。动脉血压和动脉二氧化碳浓度没有相关的变化。在另外的实验中，静脉注射吲哚美辛或AHR-5850预处理可完全抑制VIP的血管扩张作用。这些非甾体抗炎药抑制环加氧酶活性，从而干扰前列腺素和相关化合物的合成。局部组胺的血管扩张作用不受吲哚美辛和AHR-5850的影响。结果表明，VIP对猫动脉小动脉有较强的血管扩张作用，这种作用可能是由前列腺素介导的。
The effect of vasoactive intestinal polypeptide (VIP) on cerebral arterioles was examined in anesthetized cats equipped with an acutely implanted cranial window for the observation of the pial microcirculation. Topical application of VIP on the surface of the brain in doses of 0.01-1.0 microgram/ml produced a dose-related vasodilation that was of equal magnitude in small (< 100 micrometer diam) and large (> 100 micrometer diam) pial arterioles. The maximum dilation averaged 20% of the control diameter. There were no associated changes in arterial blood pressure or in arterial CO2 tension. In additional experiments the vasodilator effect of VIP was completely inhibited by pretreatment with intravenous indomethacin or AHR-5850. These nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase activity and thereby interfere with the synthesis of prostaglandins and related compounds. The vasodilator effect to topical histamine was unaffected by indomethacin and AHR-5850. The results show that VIP has a strong vasodilator effect on pial arterioles of the cat and suggest that this effect is mediated by prostaglandins.