Chromosomal location of the regulator of mouse alpha-fetoprotein, Afr-1.
Chromosomal location of the regulator of mouse alpha-fetoprotein, Afr-1.
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小鼠甲胎蛋白调节因子 Afr-1 的染色体位置。
DOI：
10.1093/genetics/119.3.687
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发表时间：
1988
期刊：
影响因子：
3.3
通讯作者：
Potter,M
中科院分区：
文献类型：
--
作者：
Blankenhorn,EP;Duncan,R;Huppi,K;Potter,M
Afr-1是一个基因，其产物有助于成年小鼠甲胎蛋白（AFP）的调节。在Afr-1 B/B纯合子中，成年血清AFP水平比Afr-1a/a或Afr-1a/B小鼠高10- 20倍。本文报道的研究是为了绘制Afr-1基因。我们的研究结果表明，Afr-1位于小鼠15号染色体上，距离Gdc-1约25 cM。Afr-1似乎位于小鼠c-myc癌基因附近。这些结果进行了讨论，相对于不同的BALB/c亚系（这是无论是Afr-1a或Afr-1b，分别）降植烷诱导的浆细胞瘤的易感性或耐药性。
Afr-1 is a gene whose product contributes to the adult regulation of mouse alpha-fetoprotein (AFP). In Afr-1b/b homozygotes, the adult serum levels of AFP are 10- to 20-fold higher than in Afr-1a/a or Afr-1a/b mice. The studies reported here were performed to map the Afr-1 gene. Our results show that Afr-1 resides on mouse chromosome 15, approximately 25 cM from Gdc-1. Afr-1 appears to be located in close proximity to the mouse c-myc oncogene. These results are discussed with respect to the susceptibility or resistance of different BALB/c sublines (which are either Afr-1a or Afr-1b, respectively) to pristane-induced plasmacytomas.