Dominant surface stress driven by biomolecular interactions in the dynamical response of nanomechanical microcantilevers
Dominant surface stress driven by biomolecular interactions in the dynamical response of nanomechanical microcantilevers
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DOI：
10.1063/1.2372700
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发表时间：
2006-10-23
影响因子：
4
通讯作者：
Park, Jung Ho
中科院分区：
文献类型：
--
作者：
Hwang, Kyo Seon;Eom, Kilho;Park, Jung Ho
纳米力学微悬臂在检测生物分子相互作用方面发挥了重要作用。微悬臂检测生物分子相互作用的能力归因于由生物分子相互作用引起的表面应力主导微悬臂动力响应的原理。本文通过实验研究了生物分子相互作用与微悬臂梁动力学响应之间的关系。此外，作者采用机械梁模型，通过测量共振频移来计算表征生物分子相互作用的表面应力。由特定蛋白质-蛋白质相互作用驱动的表面应力的定量分析表明，微悬臂能够定量研究生物分子相互作用。(c) 2006年美国物理研究所。
Nanomechanical microcantilevers have played a vital role in detecting biomolecular interactions. The ability of microcantilevers to detect biomolecular interactions is ascribed to the principle that the surface stress, caused by biomolecular interactions, dominates the dynamical response of the microcantilever. Here we have experimentally studied the correlation between biomolecular interactions and the dynamical response of microcantilevers. Moreover, the authors employed a mechanical beam model to calculate the surface stress, representing the biomolecular interactions, through measuring the resonant frequency shift. The quantitative analysis of surface stress, driven by the specific protein-protein interactions, demonstrated that microcantilevers enable the quantitative study of biomolecular interactions. (c) 2006 American Institute of Physics.