EVALUATION OF COMPARATIVE AND COMBINED ANTIMUTAGENIC POTENTIAL OF VITAMIN C AND VITAMIN E USING HISTIDINE MUTANT SALMONELLA TYPHIMURIUM STRAINS
EVALUATION OF COMPARATIVE AND COMBINED ANTIMUTAGENIC POTENTIAL OF VITAMIN C AND VITAMIN E USING HISTIDINE MUTANT SALMONELLA TYPHIMURIUM STRAINS
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DOI：
10.1007/s12291-008-0006-6
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发表时间：
2008-01-01
影响因子：
2.1
通讯作者：
Thomas, Joe
中科院分区：
文献类型：
--
作者：
Ajith, T. A.;Ann, Marry;Thomas, Joe
化学预防代表了一种新的干预策略，用于控制某些类型的致癌作用，特别是对于癌症发展高风险的受试者。实验和流行病学数据表明，包括维生素 C 和 E 在内的多种营养因子可有效降低某些类型癌症的风险。然而大型前瞻性研究未能发现如此显着的关联。使用 Ame 的鼠伤寒沙门氏菌测试法评估了两种抗氧化剂维生素抗坏血酸（维生素 C）和 α-生育酚（维生素 E）的比较和组合体外抗突变潜力。直接作用的诱变剂如叠氮化钠 (NaN3) 和 4-硝基邻苯二胺 (NPDA) 以及 N-甲基-N'-硝基-N-亚硝基胍 (MNNG) 用于诱导沙门氏菌菌株 TA 98 和 TA 100 突变。维生素 C 显着 (P
Chemoprevention represents a new intervention strategy to control some type of carcinogenesis especially in subjects at high risk for cancer development. Experimental and epidemiological data indicate that a variety of nutritional factors including vitamin C and E are effective to lower the risk of some types of cancer. However large prospective studies have failed to find such significant association. A comparative and combined in vitro antimutagenic potential of two antioxidant vitamins ascorbic acid (vitamin C) and a-tocopherol (vitamin E) were evaluated using Ame's Salmonella typhimurium test assay. Directly acting mutagens such as sodium azide (NaN3) and 4-Nitro-o-phenylenediamine (NPDA), and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were used to induce mutation in salmonella strains TA 98 and TA 100. Vitamin C significantly (P