Learning capabilities and CA1-prefrontal synaptic plasticity in a mice model of accelerated senescence
Learning capabilities and CA1-prefrontal synaptic plasticity in a mice model of accelerated senescence
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DOI：
10.1016/j.neurobiolaging.2011.04.005
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发表时间：
2012-03-01
影响因子：
4.2
通讯作者：
Delgado-Garcia, Jose M.
中科院分区：
文献类型：
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作者：
Lopez-Ramos, Juan Carlos;Jurado-Parras, Maria Teresa;Delgado-Garcia, Jose M.
与呈现正常衰老的SAMR1小鼠相比，SAMP8小鼠代表了一种合适的加速衰老模型。5个月大的SAMP8小鼠表现出与SAMR1对照组相似的反射性眼皮反应，但不能在跟踪(230毫秒刺激间隔[ms])范式中获得经典的眨眼反应。尽管SAMP8小鼠表现出正常的双脉冲易化海马CA1-内侧前额叶突触，但输入/输出曲线研究显示，对CA1-前额叶通路的强烈刺激，场兴奋性突触后电位(FEPSP)较小。此外，SAMP8小鼠在SAMR1动物显示的连续条件反射过程中没有表现出任何CA1-前额叶突触的活动依赖的增强。此外，SAMP8小鼠在物体识别测试中表现出功能缺陷，当控制移到新的物体时，它们继续探索熟悉的物体。行为警觉的SAMP8小鼠在CA1内侧前额叶突触的长时程增强(LTP)出现显著缺陷。根据目前的结果，SAMP8小鼠在与新运动和认知能力的获得和存储直接相关的海马区和前额叶皮质回路中存在明显的功能缺陷。(C)2012 Elsevier Inc.保留所有权利。
SAMP8 mice represent a suitable model of accelerated senescence as compared with SAMR1 animals presenting normal aging. Five-month-old SAMP8 mice presented reflex eyelid responses like those of SAMR1 controls, but were incapable of acquiring classically-conditioned eye blink responses in a trace (230 milliseconds [ms] of interstimulus interval) paradigm. Although SAMP8 mice presented a normal paired-pulse facilitation of the hippocampal CA1-medial prefrontal synapse, an input/output curve study revealed smaller field excitatory postsynaptic potentials (fEPSPs) in response to strong stimulations of the CA1-prefrontal pathway. Moreover, SAMP8 mice did not show any activity-dependent potentiation of the CA1-prefrontal synapse across the successive conditioning sessions shown by SAMR1 animals. In addition, SAMP8 mice presented a functional deficit during an object recognition test, continuing to explore the familiar object when controls moved to the novel one. Alert behaving SAMP8 mice presented a significant deficit in long-term potentiation (LTP) at the CA1-medial prefrontal synapse. According to the present results, SAMP8 mice present noticeable functional deficits in hippocampal and prefrontal cortical circuits directly related with the acquisition and storage of new motor and cognitive abilities. (C) 2012 Elsevier Inc. All rights reserved.