Naloxone attenuates rat’s preference for signaled shock
Naloxone attenuates rat’s preference for signaled shock
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纳洛酮减弱大鼠对信号电击的偏好
DOI：
10.3758/bf03326621
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
M. Fanselow
中科院分区：
文献类型：
--
作者：
M. Fanselow
大鼠被限制，在羽毛球的一侧给予有信号的电击，在另一侧给予无信号的电击。偏好测试显示，在训练期间注射阿片类拮抗剂纳洛酮的大鼠没有表现出随后的侧面偏好，而生理盐水对照组的大鼠更喜欢有信号的一侧。第二个和第三个实验表明，这种纳洛酮效应不可能是由于状态依赖学习(概括减少)、对探索活动的干扰或药物使信号厌恶所致。结果提示，内源性止痛物质的释放可能构成了中枢神经系统的准备反应，介导了对信号休克的偏爱。
Rats were confined and given signaled shock on one side of a shuttlebox and unsignaled shock on the other side. Preference tests revealed that rats injected with the opiate antagonist naloxone during training showed no subsequent side preference, whereas saline control rats preferred the signaled side. The second and third experiments showed that this naloxone effect could not be due to state-dependent learning (generalization decrement), interference with exploratory activity, or the drug making the signal aversive. The results suggest that release of endogenous analgesic substances may constitute a central nervous system preparatory response which mediates a preference for signaled shock.