Degradable magnetic-response photoacoustic/up-conversion luminescence imaging-guided photodynamic/photothermal antitumor therapy
Degradable magnetic-response photoacoustic/up-conversion luminescence imaging-guided photodynamic/photothermal antitumor therapy
复制标题
可降解磁响应光声/上转换发光成像引导光动力/光热抗肿瘤治疗。
DOI：
10.1039/c9bm00853e
复制
发表时间：
2019-11-01
影响因子：
6.6
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Lv, Ruichan;Jiang, Xue;Tian, Jie
在这项研究中，设计了一种可降解的均匀介孔平台作为成像引导光热疗法（PTT）/光动力疗法（PDT）剂。采用溶剂热法制备Fe3O4纳米颗粒，并通过溶胶-凝胶和刻蚀工艺在其上涂覆一层介孔SiO2，然后通过静电结合和物理吸附将这些超小型上转换纳米颗粒（UCNPs）负载到多孔结构中。通过调整刻蚀工艺，可以分别获得Fe3O4@mSiO2和高比表面积的mSiO2作为载流子主体。重要的是，该平台可以通过磁响应识别肿瘤细胞，然后呈现强烈的光声（PA）和上转换发光（UCL）信号，并且Fe3O4@mSiO2作为药物载体可以通过水解降解。此外，在单一808 nm激光下，Fe3O4@mSiO2@UCNPs的温度远高于周围组织的温度，并产生大量的单线态氧，因为UCNPs发射的蓝色发射与Fe3O4的吸收区域之间发生强烈的交叉。因此，Fe3O4@mSiO2@UCNPs可用作磁靶向双模态成像引导PTT/PDT治疗诊断探针。
In this research, a degradable uniform mesoporous platform was designed as an imaging-guided photothermal therapy (PTT)/photodynamic therapy (PDT) agent. Fe3O4 nanoparticles were prepared using the solvothermal method, and a layer of mesoporous SiO2 was coated onto them using sol-gel and etching processes, then these ultra-small up-conversion nanoparticles (UCNPs) were loaded into the porous structure through electrostatic conjunction and physical absorption. By adjusting the etching processes, Fe3O4@mSiO2 and mSiO2 with a high surface area as a carrier host could be obtained separately. Importantly, the platform could recognize the tumor cells with a magnetic-response and then present strong photoacoustic (PA) and up-conversion luminescence (UCL) signals, and Fe3O4@mSiO2 as drug carriers could be degraded by hydrolysis. Furthermore, under a single 808 nm laser, the temperature of Fe3O4@mSiO2@UCNPs rises much higher than that of the surrounding tissues, and produces a large amount of singlet oxygen because a strong crossover occurs between the emitted blue emission of the UCNPs and the absorbance region of Fe3O4. Therefore, the Fe3O4@mSiO2@UCNPs can be used as a magnetic-targeted dual-modal imaging guided PTT/PDT theranostic probe.