The manifold actions of neurotensin: a first synthesis.
The manifold actions of neurotensin: a first synthesis.
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神经降压素的多种作用：第一次合成。
DOI：
10.1111/j.1749-6632.1982.tb31582.x
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发表时间：
1982
影响因子：
5.2
通讯作者：
Nemeroff,CB
中科院分区：
文献类型：
--
作者：
PrangeJr,AJ;Nemeroff,CB
综述了神经紧张素（NT）对中枢和外周功能的影响、与多巴胺的相互作用、被促甲状腺素释放激素拮抗的作用以及操作对中枢多巴胺和NT系统的影响。研究表明，NT可能与相关物质协同作用，通过同时刺激和抑制神经解剖系统中的多巴胺通路来减少精神分裂症患者的s间和s内变异性，而神经解剖系统最有可能服务于精神分裂症的故障功能：中脑边缘系统。这样的影响将是一个充分的理由考虑NT作为内源性抗精神病药物。（23 ref）（PsycINFO Database Record (c) 2016 APA，版权所有）
Summarizes data on the effects of neurotensin (NT) on central and peripheral functions, its interactions with dopamine, its effects that are antagonized by thyrotropin-releasing hormone, and effects of manipulations on central dopamine and NT systems. It is suggested that NT, perhaps in concert with related substances, may reduce inter-and intra-S variability in schizophrenics by simultaneously stimulating and inhibiting dopamine pathways in the neuroanatomical system that most plausibly serve the functions at fault in schizophrenia: the mesolimbic system. Such an effect would be a sufficient reason to consider NT as an endogenous neuroleptic substance.(23 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)