E-cigarette or Vaping Product Use-Associated Lung Injury Produced in an Animal Model From Electronic Cigarette Vapor Exposure Without Tetrahydrocannabinol or Vitamin E Oil.
E-cigarette or Vaping Product Use-Associated Lung Injury Produced in an Animal Model From Electronic Cigarette Vapor Exposure Without Tetrahydrocannabinol or Vitamin E Oil.
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DOI：
10.1161/jaha.120.017368
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发表时间：
2020-09-15
影响因子：
5.4
通讯作者：
Kloner RA
中科院分区：
文献类型：
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作者：
Kleinman MT;Arechavala RJ;Herman D;Shi J;Hasen I;Ting A;Dai W;Carreno J;Chavez J;Zhao L;Kloner RA
2019 年夏天，美国发现了与电子烟或电子烟产品使用相关的肺损伤，其典型症状是与电子烟相关的急性呼吸窘迫、气短、胸痛、咳嗽和发烧。它可以模仿 2019 年冠状病毒病 (COVID-19) 的许多表现。一些研究人员认为，电子烟或电子烟产品使用相关的肺损伤是由于四氢大麻酚或维生素 E 醋酸酯油与电子烟液体混合所致。在最初旨在研究电子烟使用对心血管系统影响的实验性啮齿动物研究中，我们观察到与电子烟或电子烟产品使用相关的肺损伤样病症，这种病症在不使用四氢大麻酚、维生素 E 或尼古丁的情况下，在高功率使用镍铬合金加热元件后急剧发生。肺部病变包括肺泡壁增厚、炎症灶、红细胞充血、肺泡腔闭塞，以及某些病例的肺炎；支气管显示纤维蛋白、炎症细胞和粘液栓的积累。应提醒电子烟使用者注意在高设置下操作电子烟装置的潜在危险；某些加热元件可能有害；并且电子烟或电子烟产品使用相关的肺损伤可能不依赖于四氢大麻酚、维生素 E 或尼古丁。
E‐cigarette or vaping product use–associated lung injury was recognized in the United States in the summer of 2019 and is typified by acute respiratory distress, shortness of breath, chest pain, cough, and fever, associated with vaping. It can mimic many of the manifestations of coronavirus disease 2019 (COVID‐19). Some investigators have suggested that E‐cigarette or vaping product use–associated lung injury was due to tetrahydrocannabinol or vitamin E acetate oil mixed with the electronic cigarette liquid. In experimental rodent studies initially designed to study the effect of electronic cigarette use on the cardiovascular system, we observed an E‐cigarette or vaping product use–associated lung injury‐like condition that occurred acutely after use of a nichrome heating element at high power, without the use of tetrahydrocannabinol, vitamin E, or nicotine. Lung lesions included thickening of the alveolar wall with foci of inflammation, red blood cell congestion, obliteration of alveolar spaces, and pneumonitis in some cases; bronchi showed accumulation of fibrin, inflammatory cells, and mucus plugs. Electronic cigarette users should be cautioned about the potential danger of operating electronic cigarette units at high settings; the possibility that certain heating elements may be deleterious; and that E‐cigarette or vaping product use–associated lung injury may not be dependent upon tetrahydrocannabinol, vitamin E, or nicotine.