Semihydrophobic Nanoparticle-Induced Disruption of Supported Lipid Bilayers: Specific Ion Effect
Semihydrophobic Nanoparticle-Induced Disruption of Supported Lipid Bilayers: Specific Ion Effect
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DOI：
10.1021/jp5074945
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发表时间：
2014-11-20
影响因子：
3.3
通讯作者：
Zhu, Yingxi
中科院分区：
文献类型：
--
作者：
Jing, Benxin;Abot, Rosary C. T.;Zhu, Yingxi
纳米粒子与细胞膜的相互作用对于理解和控制药物和医学诊断中细胞膜的结构变化和分子运输至关重要，其中经常涉及疏水相互作用。我们研究了在添加不同类型盐的水介质中，特定离子对半疏水纳米颗粒与两性离子磷脂双层相互作用的影响。具体来说，我们比较了不同阴离子或阳离子对羧基功能化聚苯乙烯纳米颗粒在支撑脂质双层上的吸附及其诱导的双层破坏的影响。通过在纳米粒子脂质双层界面添加相同离子浓度的不同阴离子，我们观察到纳米粒子诱导的脂质贫乏区域的生长速率遵循精确的霍夫迈斯特阴离子顺序：CH3COO > Cl > NO3 >> SCN，这表明阴离子调节疏水相互作用。相反，特定阳离子对纳米颗粒诱导的脂质双层破坏率的影响并不遵循霍夫迈斯特阳离子顺序，而是表现出类似于Rb+>Na+>>N(CH3)(4)(+)的Cs+趋势。有人建议，可以利用特定离子的效应作为一种简单而有效的方法来改变纳米颗粒生物膜的相互作用，这对于药物输送到无毒纳米材料设计都有着重要意义。
The interaction of nanoparticles with cell membranes is critical to understand and control the structural change and molecular transport of cell membranes for medicines and medical diagnostics, in which hydrophobic interaction is often involved. We examine the specific ion effect on the interaction of semihydrophobic nanoparticle with zwitterionic phospholipid bilayer in aqueous media added with different types of salts. Specifically, we compare the effect of different anions or cations on the adsorption of carboxyl-functionalized polystyrene nanoparticle on supported lipid bilayer and its induced bilayer disruption. By adding different anions at the same ionic concentration to the nanoparticlelipid bilayer interface, we observe that the growth rate of nanoparticle-induced lipid-poor regions follows the exact Hofmeister anion order of CH3COO > Cl > NO3 >> SCN , suggesting the regulated hydrophobic interaction by anions. In contrast, the specific cation effect on nanoparticle-induced disruption rate of lipid bilayer does not follow the Hofmeister cation order and instead exhibits a trend of Cs+ similar to Rb+ > Na+ >> N(CH3)(4)(+). It is suggested that the effect of specific ions can be exploited as a simple and efficient approach to modify the nanoparticlesbiomembrane interactions with the implication from drug delivery to nontoxic nanomaterial design.